Tclin HRH2 Histamine H2 receptor

Protein Summary

Description

The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• P25021
• B5BUP7
• Q14464
• Q7Z5R9
• H2R

Gene Name

• HRH2

Ensembl ID

• ENST00000231683
• ENSP00000231683
• ENSG00000113749
• ENST00000377291
• ENSP00000366506

Symbol

• H2R
• HH2R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.86
drug	0.79
transcription factor	0.74
molecular function	0.7
ligand (chemical)	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Histamine H2 Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Histamine Receptor / Histamine H2 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1906.66   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 319   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1906.66   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 93

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11