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Tclin
HRH2
Histamine H2 receptor

Protein Summary
Description
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been foun ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231683
  • ENSP00000231683
  • ENSG00000113749
  • ENST00000377291
  • ENSP00000366506

Symbol
  • H2R
  • HH2R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.86
drug
0.79
transcription factor
0.74
molecular function
0.7
ligand (chemical)
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1828.21   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1828.21   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (11)
famotidine
Rendered image for famotidine
asenapine
Rendered image for asenapine
pitolisant
Rendered image for pitolisant
cimetidine
Rendered image for cimetidine
histamine
Rendered image for histamine
ranitidine
Rendered image for ranitidine
betazole
Rendered image for betazole
nizatidine
Rendered image for nizatidine
roxatidine acetate
Rendered image for roxatidine acetate
niperotidine
Rendered image for niperotidine
Protein-Protein Interactions (158)
SCT
Tbio
Novelty:  0.00070278
Score:  0.935
Data Source:  STRINGDB
PTGER4
Tclin
Family:  GPCR
Novelty:  0.0008127
Score:  0.925
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.925
Data Source:  STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.923
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.923
Data Source:  STRINGDB
GPR27
Tbio
Family:  GPCR
Novelty:  0.164488
Score:  0.923
Data Source:  STRINGDB
ADCYAP1R1
Tchem
Family:  GPCR
Novelty:  0.00786286
Score:  0.921
Data Source:  STRINGDB
VIP
Tbio
Novelty:  0.00024946
Score:  0.92
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.916
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histamine receptor H2
VGNC:4039
471750
Macaque
histamine receptor H2
695226
Mouse
MGI:108482
15466
Rat
RGD:2831
25461
Dog
histamine receptor H2
VGNC:41787
403812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histamine receptor H2
Macaque
histamine receptor H2
Mouse
Rat
Dog
histamine receptor H2
Publication Statistics
PubMed Score 1828.21
PubMed score by year
PubTator Score 1054.04
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title