Protein Summary
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been foun ...more
- ENST00000231683
- ENSP00000231683
- ENSG00000113749
- ENST00000377291
- ENSP00000366506
- H2R
- HH2R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.86 | ||
drug | 0.79 | ||
transcription factor | 0.74 | ||
molecular function | 0.7 | ||
ligand (chemical) | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1828.21 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 319 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1828.21 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 319 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 64
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 11
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (11)
Active Ligands (64)
Protein-Protein Interactions (158)
Nearest Tclin Targets
Pathways (16)
Reactome (8)
KEGG (3)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (4)
Components (3)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (0)
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IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histamine receptor H2 | VGNC:4039 | 471750 | |||||
Macaque | histamine receptor H2 | 695226 | ||||||
Mouse | MGI:108482 | 15466 | ||||||
Rat | RGD:2831 | 25461 | ||||||
Dog | histamine receptor H2 | VGNC:41787 | 403812 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histamine receptor H2 | |||||
Macaque | histamine receptor H2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histamine receptor H2 | |||||
Publication Statistics
PubMed Score 1828.21
PubMed score by year
PubTator Score 1054.04
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (69)
GeneRif Annotations (49)
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