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Tbio
POLR2A
DNA-directed RNA polymerase II subunit RPB1

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000572844
  • ENSP00000461879
  • ENSG00000181222

Symbol
  • POLR2
  • RPB1
  • RPO2
  • POLR2
  • POLRA
  • RPBh1
  • RPOL2
  • RpIILS
  • hsRPB1
  • hRPB220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
co-expressed gene
0.99
kinase
0.99
phosphatase
0.99
protein domain
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.22   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 716   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.22   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 716   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0