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Tbio
POLR2A
DNA-directed RNA polymerase II subunit RPB1

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000572844
  • ENSP00000461879
  • ENSG00000181222

Symbol
  • POLR2
  • RPB1
  • RPO2
  • POLR2
  • POLRA
  • RPBh1
  • RPOL2
  • RpIILS
  • hsRPB1
  • hRPB220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
co-expressed gene
0.99
kinase
0.99
phosphatase
0.99
protein domain
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 546.85   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 716   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 546.85   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 716   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (903)
1 – 10 of 903
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999776793
p_ni:  0.000223207
Score:  0.267
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.999590487
p_ni:  0.000409513
Score:  0.989
Data Source:  BioPlex,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.99951554
p_ni:  0.00048446
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999121975
p_ni:  0.000878025
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR2M
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999069256
p_ni:  0.000930744
Score:  0.831
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.998897431
p_ni:  0.001102569
Score:  0.712
Data Source:  BioPlex,STRINGDB
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.99767494
p_ni:  0.00232506
Score:  0.679
Data Source:  BioPlex,STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.986464329
p_ni:  0.013535671
Score:  0.999
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.969583554
p_ni:  0.030416446
Score:  0.877
Data Source:  BioPlex,STRINGDB
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.953262272
p_ni:  0.046737728
Data Source:  BioPlex
Pathways (75)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
DNA Repair
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Repair
Developmental Biology
Gene Ontology Terms (25)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
5
22
26
99.9
serum non-albumin protein measurement
3
6
8
98.8
blood protein measurement
2
5
5
97
sex hormone-binding globulin measurement
5
2
6
96.3
albumin:globulin ratio measurement
1
2
2
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
26
99.9
serum non-albumin protein measurement
8
98.8
blood protein measurement
5
97
sex hormone-binding globulin measurement
6
96.3
albumin:globulin ratio measurement
2
94.1
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98086
20020
Rat
RGD:1587326
363633
Dog
RNA polymerase II subunit A
VGNC:44792
479483
Horse
RNA polymerase II subunit A
VGNC:21673
100072997
Cow
RNA polymerase II subunit A
VGNC:33135
282312
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RNA polymerase II subunit A
Horse
RNA polymerase II subunit A
Cow
RNA polymerase II subunit A
Publication Statistics
PubMed Score 546.85
PubMed score by year
PubTator Score 142.19
PubTator score by year