You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CYP2F1
Cytochrome P450 2F1

Protein Summary
Description
May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331105
  • ENSP00000333534
  • ENSG00000197446
  • ENST00000532164
  • ENSP00000471416

Symbol
  • C2F1
  • CYP2F
  • CYPIIF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
gene perturbation
0.68
pathway
0.61
protein domain
0.58
disease perturbation
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.79   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.79   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88608
13107
Rat
RGD:2476
54246
Dog
cytochrome P450 family 2 subfamily F member 1
VGNC:50386
612477
Horse
cytochrome P450 family 2 subfamily F member 1
VGNC:50429
100068315
Cow
cytochrome P450 2F3
615697
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cytochrome P450 family 2 subfamily F member 1
Horse
cytochrome P450 family 2 subfamily F member 1
Cow
cytochrome P450 2F3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P24903-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
CYP2E1 reactions
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Fatty acids
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
CYP2E1 reactions
Cytochrome P450 - arranged by substrate type
Fatty acids
Metabolism
Gene Ontology Terms (20)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (42)
1 – 10 of 42
EPHX1
Tchem
Family: Enzyme
Novelty: 0.00220169
Score: 0.944
Data Source: STRINGDB
GSTM1
Tbio
Family: Enzyme
Novelty: 0.00023264
Score: 0.76
Data Source: STRINGDB
HPGDS
Tchem
Family: Enzyme
Novelty: 0.00019629
Score: 0.759
Data Source: STRINGDB
GSTP1
Tchem
Family: Enzyme
Novelty: 0.00045452
Score: 0.753
Data Source: STRINGDB
GSTA3
Tbio
Family: Enzyme
Novelty: 0.02008269
Score: 0.736
Data Source: STRINGDB
GSTA1
Tchem
Family: Enzyme
Novelty: 0.00308319
Score: 0.731
Data Source: STRINGDB
GSTA5
Tbio
Family: Enzyme
Novelty: 0.0799119
Score: 0.728
Data Source: STRINGDB
GSTO2
Tbio
Family: Enzyme
Novelty: 0.01836256
Score: 0.724
Data Source: STRINGDB
GSTT2B
Tbio
Family: Enzyme
Novelty: 0.02334158
Score: 0.719
Data Source: STRINGDB
ERP29
Tbio
Novelty: 0.0132632
Score: 0.716
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.79

PubMed score by year
PubTator Score  29.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer