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Tchem
CCNE1
G1/S-specific cyclin-E1

Protein Summary
Description
Essential for the control of the cell cycle at the G1/S (start) transition. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262643
  • ENSP00000262643
  • ENSG00000105173
  • ENST00000444983
  • ENSP00000410179

Symbol
  • CCNE
  • CCNE
  • pCCNE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
virus perturbation
0.94
PubMedID
0.92
biological term
0.84
kinase perturbation
0.84


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.68   (req: < 5)
Gene RIFs: 225   (req: <= 3)
Antibodies: 1089   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.68   (req: >= 5)
Gene RIFs: 225   (req: > 3)
Antibodies: 1089   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL488436
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin E1
VGNC:2368
455914
Macaque
cyclin E1
700589
Mouse
MGI:88316
12447
Rat
RGD:2294
25729
Dog
cyclin E1
VGNC:38898
484610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin E1
Macaque
cyclin E1
Mouse
Rat
Dog
cyclin E1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P24864-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (88)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
CDK-mediated phosphorylation and removal of Cdc6
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
CDK-mediated phosphorylation and removal of Cdc6
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (29)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (347)
1 – 10 of 347
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999999979
p_ni: 4e-9
p_wrong: 1.7e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999999949
p_ni: 3e-9
p_wrong: 4.8e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDK3
Tchem
Family: Kinase
Novelty: 0.03380289
p_int: 0.999993492
p_ni: 0.000006508
Score: 0.962
Data Source: BioPlex,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
p_int: 0.998873777
p_ni: 0.000097202
p_wrong: 0.001029021
Score: 0.991
Data Source: BioPlex,STRINGDB
CKS2
Tbio
Family: Enzyme
Novelty: 0.02482411
p_int: 0.998789887
p_ni: 0.000035525
p_wrong: 0.001174587
Score: 0.946
Data Source: BioPlex,STRINGDB
CKS1B
Tbio
Family: Enzyme
Novelty: 0.00766779
p_int: 0.998725846
p_ni: 0.00003286
p_wrong: 0.001241294
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
CDK7
Tchem
Family: Kinase
Novelty: 0.00322814
p_int: 0.968478594
p_ni: 0.031507904
p_wrong: 0.000013502
Score: 0.963
Data Source: BioPlex,STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
p_int: 0.844911256
p_ni: 0.154957535
p_wrong: 0.000131209
Score: 0.854
Data Source: BioPlex,STRINGDB
CDK4
Tclin
Family: Kinase
Novelty: 0.00036742
Score: 0.999
Data Source: STRINGDB
CDKN1B
Tbio
Family: Enzyme
Novelty: 0.00069449
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  377.68

PubMed score by year
PubTator Score  208.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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