Protein Classes
Protein Summary
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs ...more
- ENST00000520429
- ENSP00000428982
- ENSG00000112237
- ENST00000523799
- ENSP00000430014
- ENST00000523985
- ENSP00000430119
- CycC
- SRB11
- hSRB11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
pathway | 0.95 | ||
transcription factor binding site profile | 0.88 | ||
drug perturbation | 0.87 | ||
PubMedID | 0.82 | ||
transcription factor perturbation | 0.74 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 155.22 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 300 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 155.22 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 300 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (25)
1 – 5 of 25
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (25)
Reactome (24)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 24
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Developmental Biology | ||||
Disease | ||||
Diseases of signal transduction | ||||
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (163)
1 – 10 of 163
MED18
Family: Enzyme
Novelty: 0.00819084
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
CDK19
Family: Kinase
Novelty: 0.03661427
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
MED1
Family: Enzyme
Novelty: 0.01259825
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
CDK8
Family: Kinase
Novelty: 0.00701006
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MED21
Family: Enzyme
Novelty: 0.07350796
p_int: 1
Score: 0.993
Data Source: BioPlex,STRINGDB
MED7
Family: Enzyme
Novelty: 0.074367
p_int: 0.999999998
p_ni: 2e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
MED13
Family: Enzyme
Novelty: 0.03252658
p_int: 0.999999807
p_ni: 1.93e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
MED19
Family: Enzyme
Novelty: 0.0129406
p_int: 0.999999697
p_ni: 3.03e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
MED12L
Family: Enzyme
Novelty: 0.1277765
p_int: 0.999999634
p_ni: 3.66e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
MED24
Family: Enzyme
Novelty: 0.06494678
p_int: 0.999999108
p_ni: 8.92e-7
Score: 0.988
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 155.22
PubMed score by year
PubTator Score 62.19
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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