Tbio CCNC Cyclin-C

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Cyclin-c

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Cyclin-c

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-c

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P24863
• B4DPZ1
• Q9H543

Gene Name

• CCNC

Ensembl ID

• ENST00000520429
• ENSP00000428982
• ENSG00000112237
• ENST00000523799
• ENSP00000430014
• ENST00000523985
• ENSP00000430119

Symbol

• CycC
• SRB11
• hSRB11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
transcription factor binding site profile	0.88
drug perturbation	0.87
PubMedID	0.82
transcription factor perturbation	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.22   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 300   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.22   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (25)

1 – 5 of 25

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (25)

Reactome (24)

WikiPathways (1)

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58 targets	R-HSA-2894862
Reactome	Constitutive Signaling by NOTCH1 PEST Domain Mutants	58 targets	R-HSA-2644606
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202

Name	Explore in Pharos	Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58 targets	R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants	58 targets	R-HSA-2644606
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202

Gene Ontology Terms (8)

Functions (2)

Components (3)

Processes (3)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein serine/threonine kinase activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (163)

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1 – 10 of 163

• See Interactions on String-DB

MED18

Tbio

Family: Enzyme

Novelty: 0.00819084

p_int: 1

Score: 0.999

Data Source: BioPlex,STRINGDB

CDK19

Tchem

Family: Kinase

Novelty: 0.03661427

p_int: 1

Score: 0.999

Data Source: BioPlex,STRINGDB

MED1

Tbio

Family: Enzyme

Novelty: 0.01259825

p_int: 1

Score: 0.999

Data Source: BioPlex,STRINGDB

CDK8

Tchem

Family: Kinase

Novelty: 0.00701006

p_int: 1

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

MED21

Tbio

Family: Enzyme

Novelty: 0.07350796

p_int: 1

Score: 0.993

Data Source: BioPlex,STRINGDB

MED7

Tbio

Family: Enzyme

Novelty: 0.074367

p_int: 0.999999998

p_ni: 2e-9

Score: 0.996

Data Source: BioPlex,STRINGDB

MED13

Tbio

Family: Enzyme

Novelty: 0.03252658

p_int: 0.999999807

p_ni: 1.93e-7

Score: 0.998

Data Source: BioPlex,STRINGDB

MED19

Tbio

Family: Enzyme

Novelty: 0.0129406

p_int: 0.999999697

p_ni: 3.03e-7

Score: 0.994

Data Source: BioPlex,STRINGDB

MED12L

Tdark

Family: Enzyme

Novelty: 0.1277765

p_int: 0.999999634

p_ni: 3.66e-7

Score: 0.979

Data Source: BioPlex,STRINGDB

MED24

Tbio

Family: Enzyme

Novelty: 0.06494678

p_int: 0.999999108

p_ni: 8.92e-7

Score: 0.988

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  155.22

PubMed score by year

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PubTator Score  62.19

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Activator
Alternative splicing
Complete proteome
Cyclin
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging