Tbio CCNC Cyclin-C

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P24863
• B4DPZ1
• Q9H543

Gene Name

• CCNC

Ensembl ID

• ENST00000520429
• ENSP00000428982
• ENSG00000112237
• ENST00000523799
• ENSP00000430014
• ENST00000523985
• ENSP00000430119

Symbol

• CycC
• SRB11
• hSRB11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
transcription factor binding site profile	0.88
drug perturbation	0.87
PubMedID	0.82
transcription factor perturbation	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.05   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 300   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.05   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (163)

Explore Interacting Targets

1 – 10 of 163

• See Interactions on String-DB

MED18

Tbio

Family:  Enzyme

Novelty:  0.04066825

p_int:  1

Score:  0.999

Data Source:  BioPlex,STRINGDB

CDK19

Tchem

Family:  Kinase

Novelty:  0.03132669

p_int:  1

Score:  0.999

Data Source:  BioPlex,STRINGDB

MED1

Tbio

Family:  Enzyme

Novelty:  0.00852082

p_int:  1

Score:  0.999

Data Source:  BioPlex,STRINGDB

CDK8

Tchem

Family:  Kinase

Novelty:  0.00508026

p_int:  1

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

MED21

Tbio

Family:  Enzyme

Novelty:  0.06996616

p_int:  1

Score:  0.993

Data Source:  BioPlex,STRINGDB

MED7

Tbio

Family:  Enzyme

Novelty:  0.04773947

p_int:  0.999999998

p_ni:  2e-9

Score:  0.996

Data Source:  BioPlex,STRINGDB

MED13

Tbio

Family:  Enzyme

Novelty:  0.02090708

p_int:  0.999999807

p_ni:  1.93e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

MED19

Tbio

Family:  Enzyme

Novelty:  0.03926689

p_int:  0.999999697

p_ni:  3.03e-7

Score:  0.994

Data Source:  BioPlex,STRINGDB

MED12L

Tdark

Family:  Enzyme

Novelty:  0.09658419

p_int:  0.999999634

p_ni:  3.66e-7

Score:  0.979

Data Source:  BioPlex,STRINGDB

MED24

Tbio

Family:  Enzyme

Novelty:  0.05466084

p_int:  0.999999108

p_ni:  8.92e-7

Score:  0.988

Data Source:  BioPlex,STRINGDB

Pathways (25)

Reactome (24)

WikiPathways (1)

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58 targets	R-HSA-2894862
Reactome	Constitutive Signaling by NOTCH1 PEST Domain Mutants	58 targets	R-HSA-2644606
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202

Name	Explore in Pharos	Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58 targets	R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants	58 targets	R-HSA-2644606
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202

Gene Ontology Terms (8)

Functions (2)

Components (3)

Processes (3)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein serine/threonine kinase activity	Traceable Author Statement (TAS)	Reactome

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
puberty onset measurement	EFO_0005677	4	1	4		33
age at menarche	EFO_0004703	1	1	1		14
enuresis	MONDO_0024290	1	1	0	1.2	11.5
daytime rest measurement	EFO_0007828	1	1	1		7.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
puberty onset measurement	EFO_0005677	4		33
age at menarche	EFO_0004703	1		14
enuresis	MONDO_0024290	0	1.2	11.5
daytime rest measurement	EFO_0007828	1		7.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Activator
Alternative splicing
Complete proteome
Cyclin
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
daytime rest measurement
enuresis
puberty onset measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cyclin C	VGNC:2655	736585
Macaque	cyclin C		694465
Mouse	cyclin C	MGI:1858199	51813
Rat	cyclin C	RGD:70905	114839
Dog	cyclin C [Source:HGNC Symbol;Acc:HGNC:1581]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cyclin C
Macaque	cyclin C
Mouse	cyclin C
Rat	cyclin C
Dog	cyclin C [Source:HGNC Symbol;Acc:HGNC:1581]

Publication Statistics

PubMed Score 171.05

PubMed score by year

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PubTator Score 62.19

PubTator score by year

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