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Tchem
DNASE1
Deoxyribonuclease-1

Protein Summary
Description
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246949
  • ENSP00000246949
  • ENSG00000213918
  • ENST00000407479
  • ENSP00000385905

Symbol
  • DNL1
  • DRNI
  • DNL1
  • DRNI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.81
virus perturbation
0.72
disease perturbation
0.68
tissue
0.61
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.76   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.76   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (66)
1 – 10 of 66
ACTA1
Tbio
Novelty: 0.00147233
Score: 0.788
Data Source: STRINGDB
WIPF1
Tbio
Novelty: 0.00848365
Score: 0.749
Data Source: STRINGDB
ACTB
Tbio
Novelty: 0.00027728
Score: 0.744
Data Source: STRINGDB
WASF2
Tbio
Novelty: 0.00106405
Score: 0.731
Data Source: STRINGDB
ACTG1
Tbio
Novelty: 0.00111542
Score: 0.723
Data Source: STRINGDB
RNASE1
Tchem
Family: Enzyme
Novelty: 0.00315931
Score: 0.672
Data Source: STRINGDB
ACTA2
Tbio
Novelty: 0.00281551
Score: 0.671
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.0000092
Score: 0.662
Data Source: STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00019614
Score: 0.611
Data Source: STRINGDB
ANAPC16
Tdark
Family: Enzyme
Novelty: 0.09302326
Score: 0.594
Data Source: STRINGDB
Publication Statistics
PubMed Score  461.76

PubMed score by year
PubTator Score  542.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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