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Tchem
DNASE1
Deoxyribonuclease-1

Protein Summary
Description
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246949
  • ENSP00000246949
  • ENSG00000213918
  • ENST00000407479
  • ENSP00000385905

Symbol
  • DNL1
  • DRNI
  • DNL1
  • DRNI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.81
virus perturbation
0.72
disease perturbation
0.68
tissue
0.61
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.83   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.83   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (66)
ACTA1
Tbio
Novelty:  0.00111813
Score:  0.788
Data Source:  STRINGDB
WIPF1
Tbio
Novelty:  0.00427982
Score:  0.749
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.744
Data Source:  STRINGDB
WASF2
Tbio
Novelty:  0.00968798
Score:  0.731
Data Source:  STRINGDB
ACTG1
Tbio
Novelty:  0.00086444
Score:  0.723
Data Source:  STRINGDB
RNASE1
Tchem
Family:  Enzyme
Novelty:  0.00198139
Score:  0.672
Data Source:  STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
Score:  0.671
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.662
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.611
Data Source:  STRINGDB
ANAPC16
Tdark
Family:  Enzyme
Novelty:  0.06353035
Score:  0.594
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
3
6
91
type 2 diabetes mellitus
4
4
2
1
88.9
glomerular filtration rate
4
3
4
84.8
neutrophil count
4
3
5
82.6
vital capacity
1
1
1
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
91
type 2 diabetes mellitus
2
1
88.9
glomerular filtration rate
4
84.8
neutrophil count
5
82.6
vital capacity
1
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxyribonuclease 1
VGNC:13699
453867
Macaque
deoxyribonuclease 1
704119
Mouse
MGI:103157
13419
Rat
RGD:2510
25633
Dog
deoxyribonuclease 1
VGNC:40023
403413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxyribonuclease 1
Macaque
deoxyribonuclease 1
Mouse
Rat
Dog
deoxyribonuclease 1
Publication Statistics
PubMed Score 340.83
PubMed score by year
PubTator Score 542.01
PubTator score by year
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Related Publications
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PMID
Year
Title