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Tbio
MYL9
Myosin regulatory light polypeptide 9

Protein Summary
Description
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279022
  • ENSP00000279022
  • ENSG00000101335
  • ENST00000346786
  • ENSP00000217313

Symbol
  • MLC2
  • MRLC1
  • MYRL2
  • LC20
  • MLC2
  • MRLC1
  • MYRL2
  • MLC-2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
kinase
0.98
PubMedID
0.88
transcription factor perturbation
0.88
disease
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.27   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.27   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
PSMD3
Tbio
Family:  Enzyme
Novelty:  0.03106272
p_int:  0.999996526
p_ni:  4e-9
p_wrong:  0.000003469
Data Source:  BioPlex
MYLK
Tchem
Family:  Kinase
Novelty:  0.00102277
Score:  0.997
Data Source:  Reactome,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.986
Data Source:  Reactome,STRINGDB
MYH9
Tbio
Novelty:  0.0016488
Score:  0.985
Data Source:  Reactome,STRINGDB
MYH14
Tchem
Novelty:  0.00874871
Score:  0.983
Data Source:  Reactome,STRINGDB
MYH10
Tchem
Novelty:  0.00624251
Score:  0.982
Data Source:  Reactome,STRINGDB
MYH11
Tbio
Novelty:  0.00142474
Score:  0.982
Data Source:  Reactome,STRINGDB
TPM2
Tbio
Novelty:  0.00406572
Score:  0.981
Data Source:  STRINGDB
PPP1R12A
Tbio
Family:  Enzyme
Novelty:  0.0028297
Score:  0.981
Data Source:  Reactome,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
ROCK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
ROCK1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
Pathways (91)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHA-mediated growth cone collapse
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
86.9
1
1
0
1.3
60.5
appendicular lean mass
1
1
1
50.6
mean corpuscular hemoglobin concentration
1
1
1
46.9
1
1
0
1.3
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
86.9
0
1.3
60.5
appendicular lean mass
1
50.6
mean corpuscular hemoglobin concentration
1
46.9
0
1.3
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 9
VGNC:6194
458216
Mouse
MGI:2138915
98932
Rat
RGD:1311235
296313
Dog
myosin light chain 9
VGNC:43547
485856
Horse
myosin light chain 9
VGNC:20488
100055199
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 9
Mouse
Rat
Dog
myosin light chain 9
Horse
myosin light chain 9
Publication Statistics
PubMed Score 299.27
PubMed score by year
PubTator Score 61.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title