Tbio TNC Tenascin

Protein Summary

Description

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• P24821
• C9IYT7
• C9J575
• C9J6D9
• C9J848
• Q14583
• Q15567
• Q5T7S3
• TN

Gene Name

• TNC

Ensembl ID

• ENST00000350763
• ENSP00000265131
• ENSG00000041982
• ENST00000537320
• ENSP00000443478

Symbol

• HXB
• GP
• JI
• TN
• HXB
• GMEM
• TN-C
• DFNA56
• 150-225

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.97
protein domain	0.97
gene perturbation	0.96
transcription factor perturbation	0.94
PubMedID	0.81

Protein Classes

DTO Classes

Tenascin-r / Tenascin-n

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.38   (req: < 5)

Gene RIFs: 252   (req: <= 3)

Antibodies: 909   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.38   (req: >= 5)

Gene RIFs: 252   (req: > 3)

Antibodies: 909   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0