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Tbio
TNC
Tenascin

Protein Classes
Protein Summary
Description
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350763
  • ENSP00000265131
  • ENSG00000041982
  • ENST00000537320
  • ENSP00000443478

Symbol
  • HXB
  • GP
  • JI
  • TN
  • HXB
  • GMEM
  • TN-C
  • DFNA56
  • 150-225
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
protein domain
0.97
gene perturbation
0.96
transcription factor perturbation
0.94
PubMedID
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.83   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 909   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.83   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 909   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
90.8
osteoarthritis, hip
2
2
0
1.1
63.9
eosinophil percentage of granulocytes
1
1
1
59
neutrophil percentage of granulocytes
1
1
1
56.8
eosinophil percentage of leukocytes
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
90.8
osteoarthritis, hip
0
1.1
63.9
eosinophil percentage of granulocytes
1
59
neutrophil percentage of granulocytes
1
56.8
eosinophil percentage of leukocytes
1
56.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tenascin C
VGNC:4885
742736
Mouse
MGI:101922
21923
Rat
RGD:621057
116640
Dog
tenascin C
VGNC:47646
481689
Horse
tenascin C
VGNC:24356
100049835
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tenascin C
Mouse
Rat
Dog
tenascin C
Horse
tenascin C
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P24821-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (40)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Reactome
Metabolism of proteins
Reactome
Non-integrin membrane-ECM interactions
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Integrin cell surface interactions
Metabolism of proteins
Non-integrin membrane-ECM interactions
Gene Ontology Terms (33)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (164)
1 – 10 of 164
ACAN
Tbio
Novelty:  0.00033695
Score:  0.985
Data Source:  Reactome,STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.964
Data Source:  Reactome,STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.941
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.936
Data Source:  STRINGDB
LAMC1
Tbio
Novelty:  0.01230796
Score:  0.936
Data Source:  STRINGDB
C4A
Tbio
Novelty:  0.00062793
Score:  0.935
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.93
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.928
Data Source:  STRINGDB
LAMB2
Tbio
Novelty:  0.07966931
Score:  0.923
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.923
Data Source:  STRINGDB
Publication Statistics
PubMed Score  194.83

PubMed score by year
PubTator Score  1911.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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