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Tchem
ACAT1
Acetyl-CoA acetyltransferase, mitochondrial

Protein Summary
Description
Plays a major role in ketone body metabolism. This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265838
  • ENSP00000265838
  • ENSG00000075239
  • ENST00000299355
  • ENSP00000299355

Symbol
  • ACAT
  • MAT
  • T2
  • MAT
  • ACAT
  • THIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.99
protein domain
0.97
interacting protein
0.93
pathway
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.62   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 539   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.62   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (13)
1 – 10 of 13
CHEMBL3890942
chemical structure image
CHEMBL454397
chemical structure image
compound 15a [PMID: 16242323]
chemical structure image
compound 15b [PMID: 16242323]
chemical structure image
compound 16 [PMID: 16242323]
chemical structure image
compound 18a [PMID: 16242323]
chemical structure image
compound 18b [PMID: 16242323]
chemical structure image
compound 22c [PMID: 16242323]
chemical structure image
compound 22d [PMID: 16242323]
chemical structure image
compound 26a [PMID: 16242323]
chemical structure image
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA acetyltransferase 1
VGNC:3234
451528
Macaque
acetyl-CoA acetyltransferase 1
707653
Mouse
MGI:87870
110446
Rat
RGD:2016
25014
Dog
acetyl-CoA acetyltransferase 1
VGNC:37498
489421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA acetyltransferase 1
Macaque
acetyl-CoA acetyltransferase 1
Mouse
Rat
Dog
acetyl-CoA acetyltransferase 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P24752-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Ketone body metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Ketone body metabolism
Metabolism
Metabolism of amino acids and derivatives
Metabolism of lipids
Gene Ontology Terms (30)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (152)
1 – 10 of 152
PDSS2
Tbio
Family: Enzyme
Novelty: 0.02716477
p_int: 0.999850293
p_ni: 0.000147377
p_wrong: 0.00000233
Score: 0.356
Data Source: BioPlex,STRINGDB
ACAT2
Tchem
Family: Enzyme
Novelty: 0.01464168
p_int: 0.853883349
p_ni: 0.146116651
Score: 0.947
Data Source: BioPlex,STRINGDB
HADH
Tbio
Family: Enzyme
Novelty: 0.00368073
Score: 0.991
Data Source: STRINGDB
HADHA
Tbio
Novelty: 0.00385746
Score: 0.986
Data Source: STRINGDB
HMGCS1
Tchem
Family: Enzyme
Novelty: 0.01089288
Score: 0.984
Data Source: STRINGDB
HMGCS2
Tbio
Family: Enzyme
Novelty: 0.0103808
Score: 0.982
Data Source: STRINGDB
OXCT1
Tbio
Family: Enzyme
Novelty: 0.00283394
Score: 0.978
Data Source: STRINGDB
ACADS
Tbio
Family: Enzyme
Novelty: 0.00841051
Score: 0.972
Data Source: STRINGDB
EHHADH
Tbio
Novelty: 0.00878193
Score: 0.967
Data Source: STRINGDB
ACAA2
Tbio
Family: Enzyme
Novelty: 0.01452373
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.62

PubMed score by year
PubTator Score  258.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer