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Tchem
PRKCH
Protein kinase C eta type

Protein Classes
Protein Summary
Description
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epith ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332981
  • ENSP00000329127
  • ENSG00000027075
  • ENST00000555082
  • ENSP00000450981

Symbol
  • PKCL
  • PRKCL
  • PKCL
  • PKC-L
  • PRKCL
  • nPKC-eta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
PubMedID
0.97
drug perturbation
0.87
trait
0.86


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.62   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.62   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 97
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
55.8
1
1
0
1.1
40.8
gut microbiome measurement
1
1
1
40.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
55.8
0
1.1
40.8
gut microbiome measurement
1
40.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C eta
VGNC:12587
746068
Mouse
MGI:97600
18755
Rat
RGD:621888
81749
Dog
protein kinase C eta
VGNC:44981
490722
Horse
protein kinase C eta
VGNC:21846
100051560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C eta
Mouse
Rat
Dog
protein kinase C eta
Horse
protein kinase C eta
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P24723-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (46)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
G alpha (z) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
G alpha (z) signalling events
GPCR downstream signalling
Hemostasis
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (94)
1 – 10 of 94
PRKCE
Tchem
Family: Kinase
Novelty: 0.00890161
p_int: 0.999999971
p_wrong: 2.9e-8
Score: 0.901
Data Source: BioPlex,STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
p_int: 0.999975418
p_wrong: 0.000024582
Score: 0.939
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.937
Data Source: STRINGDB
GNG7
Tbio
Novelty: 0.08478455
Score: 0.936
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.934
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.933
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.933
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.92
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.919
Data Source: STRINGDB
ADRA2C
Tclin
Family: GPCR
Novelty: 0.00661399
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.62

PubMed score by year
PubTator Score  44.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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