Tchem ACP1 Low molecular weight phosphotyrosine protein phosphatase

Protein Summary

Description

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• P24666
• A8K1L9
• B5MCC7
• P24667
• Q16035
• Q16036
• Q16725
• Q3KQX8
• Q53RU0
• LMW-PTP

Gene Name

• ACP1

Ensembl ID

• ENST00000272065
• ENSP00000272065
• ENSG00000143727
• ENST00000272067
• ENSP00000272067
• ENST00000407983
• ENSP00000385404

Symbol

• HAAP
• LMWPTP
• LMW-PTP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
co-expressed gene	0.93
transcription factor perturbation	0.88
interacting protein	0.87
histone modification site profile	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.32   (req: < 5)

Gene RIFs: 74   (req: <= 3)

Antibodies: 379   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.32   (req: >= 5)

Gene RIFs: 74   (req: > 3)

Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0