You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
IGFBP6
Insulin-like growth factor-binding protein 6

Protein Summary
Description
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301464
  • ENSP00000301464
  • ENSG00000167779

Symbol
  • IBP6
  • IBP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
disease perturbation
0.87
protein domain
0.85
small molecule perturbation
0.82
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.33   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.33   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (25)
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.99895487
p_ni:  0.001045129
p_wrong:  1e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
PPP3CC
Tbio
Family:  Enzyme
Novelty:  0.02633046
p_int:  0.965669062
p_ni:  0.034152488
p_wrong:  0.00017845
Score:  0.638
Data Source:  BioPlex,STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
p_int:  0.957763558
p_ni:  0.042236441
Score:  0.561
Data Source:  BioPlex,STRINGDB
CDK19
Tchem
Family:  Kinase
Novelty:  0.03132669
p_int:  0.840813021
p_ni:  0.159186979
Score:  0.198
Data Source:  BioPlex,STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.823385602
p_ni:  0.176614388
p_wrong:  1e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.997
Data Source:  Reactome,STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.994
Data Source:  Reactome,STRINGDB
IGFALS
Tbio
Novelty:  0.0287658
Score:  0.822
Data Source:  STRINGDB
SOAT2
Tchem
Family:  Enzyme
Novelty:  0.01860981
Score:  0.805
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.671
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
2
3
66.8
systolic blood pressure
2
2
2
60.9
educational attainment
1
3
3
58.9
appendicular lean mass
1
1
1
57.1
cholesteryl esters:total lipids ratio
1
1
1
54.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
66.8
systolic blood pressure
2
60.9
educational attainment
3
58.9
appendicular lean mass
1
57.1
cholesteryl esters:total lipids ratio
1
54.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 6
VGNC:5428
451929
Mouse
MGI:96441
16012
Rat
RGD:2877
25641
Dog
insulin like growth factor binding protein 6
VGNC:41907
607374
Horse
insulin like growth factor binding protein 6
VGNC:18975
100034156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 6
Mouse
Rat
Dog
insulin like growth factor binding protein 6
Horse
insulin like growth factor binding protein 6
Publication Statistics
PubMed Score 164.33
PubMed score by year
PubTator Score 170.02
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title