Tchem IGFBP6 Insulin-like growth factor-binding protein 6

Protein Summary

Description

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Uniprot Accession IDs

• P24592
• Q14492
• IBP-6

Gene Name

• IGFBP6

Ensembl ID

• ENST00000301464
• ENSP00000301464
• ENSG00000167779

Symbol

• IBP6
• IBP6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
disease perturbation	0.87
protein domain	0.85
small molecule perturbation	0.82
histone modification site profile	0.81

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Insulin-like Growth Factor-binding Protein 6

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Insulin-like Growth Factor-binding Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.33   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 329   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.33   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0