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Tbio
AKAP5
A-kinase anchor protein 5

Protein Summary
Description
May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320636
  • ENSP00000315615
  • ENSG00000179841
  • ENST00000394718
  • ENSP00000378207

Symbol
  • AKAP79
  • H21
  • AKAP75
  • AKAP79
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
biological process
0.71
gene perturbation
0.68
microRNA
0.66
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.77   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.77   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
77.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 5
VGNC:12965
467480
Dog
A-kinase anchoring protein 5
VGNC:37758
480354
Horse
A-kinase anchoring protein 5
VGNC:15204
100052129
Cow
A-kinase anchoring protein 5
VGNC:25786
281612
Pig
A-kinase anchoring protein 5
100153460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 5
Dog
A-kinase anchoring protein 5
Horse
A-kinase anchoring protein 5
Cow
A-kinase anchoring protein 5
Pig
A-kinase anchoring protein 5
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P24588-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Integration of energy metabolism
Gene Ontology Terms (27)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO-UCL
Inferred from Direct Assay (IDA)
SynGO-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
SynGO-UCL
Inferred from Physical Interaction (IPI)
SynGO-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (110)
1 – 10 of 110
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
p_int: 0.999998633
p_ni: 2.5e-8
p_wrong: 0.000001342
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
p_int: 0.999997469
p_ni: 7.05e-7
p_wrong: 0.000001826
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
p_int: 0.999996905
p_ni: 0.000002833
p_wrong: 2.62e-7
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
Score: 0.986
Data Source: Reactome,STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.977
Data Source: STRINGDB
DLG1
Tbio
Novelty: 0.0050926
Score: 0.974
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.973
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.972
Data Source: STRINGDB
ADCY8
Tbio
Family: Enzyme
Novelty: 0.00510386
Score: 0.967
Data Source: STRINGDB
CALM2
Tclin
Novelty: 0.01876254
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  289.77

PubMed score by year
PubTator Score  114.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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