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Tchem
TBXAS1
Thromboxane-A synthase

Protein Summary
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.86
disease
0.73
transcription factor binding site profile
0.73
tissue sample
0.72
molecular function
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.34   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.34   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 670
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (670)
SB203580
Rendered image for SB203580
Sulconazole
Rendered image for Sulconazole
1-Benzylimidazole
Rendered image for 1-Benzylimidazole
Oxiconazole
Rendered image for Oxiconazole
CHEMBL180650
Rendered image for CHEMBL180650
Tannic acid
Rendered image for Tannic acid
compound 7p [PMID: 7861416]
Rendered image for compound 7p [PMID: 7861416]
CHEMBL338420
Rendered image for CHEMBL338420
Protein-Protein Interactions (48)
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.841854892
p_ni:  0.158145108
Score:  0.27
Data Source:  BioPlex,STRINGDB
PTGIS
Tchem
Family:  Enzyme
Novelty:  0.00183292
Score:  0.973
Data Source:  STRINGDB
PTGES
Tchem
Family:  Enzyme
Novelty:  0.00146096
Score:  0.966
Data Source:  STRINGDB
PTGS1
Tclin
Family:  Enzyme
Novelty:  0.00043214
Score:  0.965
Data Source:  STRINGDB
PTGES3
Tbio
Family:  Enzyme
Novelty:  0.0082783
Score:  0.962
Data Source:  STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
Score:  0.961
Data Source:  STRINGDB
PTGDS
Tchem
Family:  Enzyme
Novelty:  0.002111
Score:  0.954
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.952
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.937
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.665
Data Source:  STRINGDB
Pathways (21)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
74.3
4
3
3
1.1
59.7
platelet count
1
1
1
59.5
myeloid white cell count
1
1
1
54.4
monocyte count
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
74.3
3
1.1
59.7
platelet count
1
59.5
myeloid white cell count
1
54.4
monocyte count
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thromboxane A synthase 1
VGNC:4530
463774
Macaque
thromboxane A synthase 1
711748
Mouse
MGI:98497
21391
Rat
RGD:3826
24886
Dog
thromboxane A synthase 1
VGNC:47178
482771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thromboxane A synthase 1
Macaque
thromboxane A synthase 1
Mouse
Rat
Dog
thromboxane A synthase 1
Publication Statistics
PubMed Score 192.34
PubMed score by year
PubTator Score 114.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title