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Tclin
EDNRB
Endothelin receptor type B

Protein Summary
Description
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334286
  • ENSP00000335311
  • ENSG00000136160
  • ENST00000377211
  • ENSP00000366416
  • ENST00000475537
  • ENSP00000487082
  • ENST00000626030
  • ENSP00000486202
  • ENST00000646605
  • ENSP00000494278
  • ENST00000646607
  • ENSP00000493527
  • ENST00000646948
  • ENSP00000493895

Symbol
  • ETRB
  • ETB
  • ET-B
  • ETB1
  • ETBR
  • ETRB
  • HSCR
  • WS4A
  • ABCDS
  • ET-BR
  • HSCR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.94
kinase perturbation
0.93
gene perturbation
0.9
microRNA
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1754.9   (req: < 5)
Gene RIFs: 163   (req: <= 3)
Antibodies: 432   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1754.9   (req: >= 5)
Gene RIFs: 163   (req: > 3)
Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 199
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
56
balding measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
56
balding measurement
1
46.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelin receptor type B
VGNC:13086
452613
Macaque
endothelin receptor type B
697329
Mouse
MGI:102720
13618
Rat
RGD:2536
50672
Dog
endothelin receptor type B
VGNC:40203
403862
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelin receptor type B
Macaque
endothelin receptor type B
Mouse
Rat
Dog
endothelin receptor type B
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P24530-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (270)
1 – 10 of 270
KLRC4
Tbio
Novelty: 0.16922525
p_int: 0.999994638
p_ni: 0.000001515
p_wrong: 0.000003847
Data Source: BioPlex
VPS8
Tbio
Novelty: 0.05178496
p_int: 0.993901278
p_ni: 0.006089651
p_wrong: 0.00000907
Data Source: BioPlex
C1orf112
Tdark
Novelty: 1.42922586
p_int: 0.989190177
p_ni: 0.010805976
p_wrong: 0.000003847
Data Source: BioPlex
LNPEP
Tchem
Family: Enzyme
Novelty: 0.00249049
p_int: 0.982495365
p_ni: 0.017504635
Data Source: BioPlex
PXK
Tbio
Family: Kinase
Novelty: 0.02316511
p_int: 0.970160844
p_ni: 0.029835043
p_wrong: 0.000004112
Score: 0.169
Data Source: BioPlex,STRINGDB
EXOC2
Tbio
Novelty: 0.01434464
p_int: 0.963387348
p_ni: 0.036612652
Score: 0.521
Data Source: BioPlex,STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
p_int: 0.960986668
p_ni: 0.039013332
Score: 0.194
Data Source: BioPlex,STRINGDB
INTS12
Tbio
Family: Epigenetic
Novelty: 0.09023473
p_int: 0.955659544
p_ni: 0.044337202
p_wrong: 0.000003254
Data Source: BioPlex
ARFGEF1
Tbio
Novelty: 0.16148196
p_int: 0.955089616
p_ni: 0.044910384
Score: 0.193
Data Source: BioPlex,STRINGDB
KNTC1
Tbio
Novelty: 0.08083785
p_int: 0.933788686
p_ni: 0.066211314
Data Source: BioPlex
Publication Statistics
PubMed Score  1754.90

PubMed score by year
PubTator Score  703.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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