GADD45A
Growth arrest and DNA damage-inducible protein GADD45 alpha
Protein Summary
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
- ENST00000370985
- ENSP00000360024
- ENSG00000116717
- ENST00000370986
- ENSP00000360025
- DDIT1
- GADD45
- DDIT1
- GADD45
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
kinase perturbation | 1 | ||
transcription factor binding site profile | 0.98 | ||
PubMedID | 0.96 | ||
small molecule perturbation | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 534.7 (req: < 5)
Gene RIFs: 142 (req: <= 3)
Antibodies: 374 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 534.7 (req: >= 5)
Gene RIFs: 142 (req: > 3)
Antibodies: 374 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0