Tbio GADD45A Growth arrest and DNA damage-inducible protein GADD45 alpha

Protein Summary

Description

In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• P24522
• Q5TCA7
• Q5TCA8

Gene Name

• GADD45A

Ensembl ID

• ENST00000370985
• ENSP00000360024
• ENSG00000116717
• ENST00000370986
• ENSP00000360025

Symbol

• DDIT1
• GADD45
• DDIT1
• GADD45

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
kinase perturbation	1
transcription factor binding site profile	0.98
PubMedID	0.96
small molecule perturbation	0.95

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.12   (req: < 5)

Gene RIFs: 123   (req: <= 3)

Antibodies: 374   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.12   (req: >= 5)

Gene RIFs: 123   (req: > 3)

Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (150)

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1 – 10 of 150

• See Interactions on String-DB

MAP3K4

Tbio

Family:  Kinase

Novelty:  0.02186397

p_int:  0.99999976

p_ni:  2.4e-7

Score:  0.971

Data Source:  BioPlex,STRINGDB

LRIF1

Tdark

Novelty:  0.26861958

p_int:  0.980922668

p_ni:  0.019065399

p_wrong:  0.000011933

Data Source:  BioPlex

CBX4

Tchem

Family:  Epigenetic

Novelty:  0.02681197

p_int:  0.979290857

p_ni:  0.020688149

p_wrong:  0.000020995

Data Source:  BioPlex

ZZZ3

Tdark

Family:  TF

Novelty:  0.23862921

p_int:  0.961501318

p_ni:  0.038498669

p_wrong:  1.2e-8

Data Source:  BioPlex

PEAK1

Tchem

Family:  Kinase

Novelty:  0.02919858

p_int:  0.899109144

p_ni:  0.100890726

p_wrong:  1.3e-7

Data Source:  BioPlex

DDX19B

Tbio

Family:  Enzyme

Novelty:  0.0504568

p_int:  0.858923674

p_ni:  0.141076326

Data Source:  BioPlex

REXO5

Tdark

Family:  Enzyme

Novelty:  0.8782494

p_int:  0.83587087

p_ni:  0.164101484

p_wrong:  0.000027646

Data Source:  BioPlex

PRR14L

Tdark

Novelty:  1.18537007

p_int:  0.798383178

p_ni:  0.201616822

Data Source:  BioPlex

TP53

Tchem

Family:  TF

Novelty:  0.00001907

Score:  0.989

Data Source:  STRINGDB

CDK1

Tchem

Family:  Kinase

Novelty:  0.00040776

Score:  0.981

Data Source:  STRINGDB

Nearest Tclin Targets (3)

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Upstream (3)

1 – 3 of 3

MAP2K2

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  15

1: Non-small cell lung cancer

2: Chronic myeloid leukemia

3: Gastric cancer

4: Melanoma

more:  11 more common pathways

MAP2K1

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  16

1: Non-small cell lung cancer

2: Chronic myeloid leukemia

3: Gastric cancer

4: Melanoma

more:  12 more common pathways

IL6

Tclin

Family:  Other

KEGG Distance:  3

Common Pathways:  5

1: FoxO signaling pathway

2: Transcriptional misregulation in cancer

3: Pathways in cancer

4: Cellular senescence

5: Epstein-Barr virus infection

Pathways (59)

Reactome (8)

KEGG (22)

PathwayCommons (9)

WikiPathways (20)

FOXO-mediated transcription (R-HSA-9614085)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	FOXO-mediated transcription	68 targets	R-HSA-9614085
Reactome	FOXO-mediated transcription of cell cycle genes	17 targets	R-HSA-9617828
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
FOXO-mediated transcription	68 targets	R-HSA-9614085
FOXO-mediated transcription of cell cycle genes	17 targets	R-HSA-9617828
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (5)

Components (4)

Processes (17)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
protein homodimerization activity	Inferred from Direct Assay (IDA)	CAFA
protein N-terminus binding	Inferred from Direct Assay (IDA)	CAFA
kinase binding	Inferred from Physical Interaction (IPI)	CAFA
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	CAFA
RNA polymerase II core promoter sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (17)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		55.2
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		44.1
mean reticulocyte volume	EFO_0010701	1	1	1		37.6
red blood cell distribution width	EFO_0005192	2	1	2		31.3
red blood cell density measurement	EFO_0007978	1	1	1		29.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		55.2
mean corpuscular hemoglobin concentration	EFO_0004528	1		44.1
mean reticulocyte volume	EFO_0010701	1		37.6
red blood cell distribution width	EFO_0005192	2		31.3
red blood cell density measurement	EFO_0007978	1		29.8

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UniProt Keyword Find Similar Targets

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3D-structure
Alternative splicing
Cell cycle
Complete proteome
DNA damage
Growth arrest
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

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birth weight
C-reactive protein measurement
diastolic blood pressure
facial morphology measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume
mean reticulocyte volume
monocyte count
myeloid white cell count

MGI Phenotype Find Similar Targets

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cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
neoplasm
nervous system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	growth arrest and DNA damage inducible alpha	VGNC:6828	456929
Mouse	growth arrest and DNA-damage-inducible 45 alpha	MGI:107799	13197
Rat	growth arrest and DNA-damage-inducible, alpha	RGD:2654	25112
Dog	growth arrest and DNA damage inducible alpha	VGNC:41069	100855728
Cow	growth arrest and DNA damage inducible alpha	VGNC:29206	505463

Species	Name	OMA	EggNOG	Inparanoid
Chimp	growth arrest and DNA damage inducible alpha
Mouse	growth arrest and DNA-damage-inducible 45 alpha
Rat	growth arrest and DNA-damage-inducible, alpha
Dog	growth arrest and DNA damage inducible alpha
Cow	growth arrest and DNA damage inducible alpha

Publication Statistics

PubMed Score 507.12

PubMed score by year

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PubTator Score 393.28

PubTator score by year

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Related Publications

Text Mined References (159)

GeneRif Annotations (123)

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PMID	Year	Title