GADD45A
Growth arrest and DNA damage-inducible protein GADD45 alpha
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 1 | ||
kinase perturbation | 1 | ||
transcription factor binding site profile | 0.98 | ||
PubMedID | 0.96 | ||
small molecule perturbation | 0.95 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of cell cycle genes | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
FOXO-mediated transcription | ||||
FOXO-mediated transcription of cell cycle genes | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 1 | 1 | 55.2 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 44.1 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 37.6 | |||||
red blood cell distribution width | 2 | 1 | 2 | 31.3 | |||||
red blood cell density measurement | 1 | 1 | 1 | 29.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 55.2 | |||||
mean corpuscular hemoglobin concentration | 1 | 44.1 | |||||
mean reticulocyte volume | 1 | 37.6 | |||||
red blood cell distribution width | 2 | 31.3 | |||||
red blood cell density measurement | 1 | 29.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | growth arrest and DNA damage inducible alpha | VGNC:6828 | 456929 | |||||
Mouse | MGI:107799 | 13197 | ||||||
Rat | RGD:2654 | 25112 | ||||||
Dog | growth arrest and DNA damage inducible alpha | VGNC:41069 | 100855728 | |||||
Cow | growth arrest and DNA damage inducible alpha | VGNC:29206 | 505463 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | growth arrest and DNA damage inducible alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | growth arrest and DNA damage inducible alpha | |||||
Cow | growth arrest and DNA damage inducible alpha | |||||
PMID | Year | Title |
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