GADD45A
Growth arrest and DNA damage-inducible protein GADD45 alpha
Protein Summary
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
- ENST00000370985
- ENSP00000360024
- ENSG00000116717
- ENST00000370986
- ENSP00000360025
- DDIT1
- GADD45
- DDIT1
- GADD45
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
kinase perturbation | 1 | ||
transcription factor binding site profile | 0.98 | ||
PubMedID | 0.96 | ||
small molecule perturbation | 0.95 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 496.87 (req: < 5)
Gene RIFs: 123 (req: <= 3)
Antibodies: 374 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 496.87 (req: >= 5)
Gene RIFs: 123 (req: > 3)
Antibodies: 374 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 1 | 1 | 57.7 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 33 | |||||
red blood cell distribution width | 2 | 1 | 2 | 22.6 | |||||
red blood cell density measurement | 1 | 1 | 1 | 21.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 10.4 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 57.7 | |||||
mean corpuscular hemoglobin concentration | 1 | 33 | |||||
red blood cell distribution width | 2 | 22.6 | |||||
red blood cell density measurement | 1 | 21.4 | |||||
mean corpuscular volume | 1 | 10.4 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | growth arrest and DNA damage inducible alpha | VGNC:6828 | 456929 | |||||
Mouse | MGI:107799 | 13197 | ||||||
Rat | RGD:2654 | 25112 | ||||||
Dog | growth arrest and DNA damage inducible alpha | VGNC:41069 | 100855728 | |||||
Cow | growth arrest and DNA damage inducible alpha | VGNC:29206 | 505463 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | growth arrest and DNA damage inducible alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | growth arrest and DNA damage inducible alpha | |||||
Cow | growth arrest and DNA damage inducible alpha | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (59)
Reactome (8)
KEGG (22)
PathwayCommons (9)
WikiPathways (20)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of cell cycle genes | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
FOXO-mediated transcription | ||||
FOXO-mediated transcription of cell cycle genes | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Gene Ontology Terms (26)
Functions (5)
Components (4)
Processes (17)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (150)
1 – 10 of 150
MAP3K4
Family: Kinase
Novelty: 0.02186397
p_int: 0.99999976
p_ni: 2.4e-7
Score: 0.971
Data Source: BioPlex,STRINGDB
LRIF1
Novelty: 0.26861958
p_int: 0.980922668
p_ni: 0.019065399
p_wrong: 0.000011933
Data Source: BioPlex
CBX4
Family: Epigenetic
Novelty: 0.02681197
p_int: 0.979290857
p_ni: 0.020688149
p_wrong: 0.000020995
Data Source: BioPlex
ZZZ3
Family: TF
Novelty: 0.23862921
p_int: 0.961501318
p_ni: 0.038498669
p_wrong: 1.2e-8
Data Source: BioPlex
PEAK1
Family: Kinase
Novelty: 0.02919858
p_int: 0.899109144
p_ni: 0.100890726
p_wrong: 1.3e-7
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.858923674
p_ni: 0.141076326
Data Source: BioPlex
REXO5
Family: Enzyme
Novelty: 0.8782494
p_int: 0.83587087
p_ni: 0.164101484
p_wrong: 0.000027646
Data Source: BioPlex
PRR14L
Novelty: 1.18537007
p_int: 0.798383178
p_ni: 0.201616822
Data Source: BioPlex
TP53
Family: TF
Novelty: 0.00001907
Score: 0.989
Data Source: STRINGDB
CDK1
Family: Kinase
Novelty: 0.00040776
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score 496.87
PubMed score by year
PubTator Score 393.28
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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