NR2F2
COUP transcription factor 2
Protein Summary
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
- ENST00000394166
- ENSP00000377721
- ENSG00000185551
- ENST00000394171
- ENSP00000377726
- ENST00000421109
- ENSP00000401674
- ENST00000453270
- ENSP00000389853
- ARP1
- TFCOUP2
- ARP1
- ARP-1
- CHTD4
- NF-E3
- SVP40
- COUPTF2
- COUPTFB
- TFCOUP2
- COUPTFII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
molecular function | 0.99 | ||
biological process | 0.98 | ||
PubMedID | 0.95 | ||
transcription factor | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.95 (req: < 5)
Gene RIFs: 93 (req: <= 3)
Antibodies: 291 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.95 (req: >= 5)
Gene RIFs: 93 (req: > 3)
Antibodies: 291 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0