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Tclin
CYP3A7
Cytochrome P450 3A7

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336374
  • ENSP00000337450
  • ENSG00000160870

Symbol
  • CYP3A7
  • CYPIIIA7
  • CYP3A7.1L
  • CYP3A7-3AP1
  • CYP3A7-CYP3AP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
tissue sample
0.83
kinase perturbation
0.81
PubMedID
0.76
gene perturbation
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.09   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.09   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
cobicistat
chemical structure image
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
1
4
71.8
acute coronary syndrome
1
1
1
64.5
ticagrelor measurement
1
1
1
64.5
heel bone mineral density
2
1
2
40.9
estradiol measurement
1
1
1
29.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
71.8
acute coronary syndrome
1
64.5
ticagrelor measurement
1
64.5
heel bone mineral density
2
40.9
estradiol measurement
1
29.5
Pathways (10)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Reactome
Xenobiotics
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Metabolism
Phase I - Functionalization of compounds
Xenobiotics
Gene Ontology Terms (12)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
p_int: 0.999999995
p_wrong: 5e-9
Score: 0.957
Data Source: BioPlex,STRINGDB
CYP3A5
Tclin
Family: Enzyme
Novelty: 0.00105607
p_int: 0.999999926
p_wrong: 7.5e-8
Score: 0.969
Data Source: BioPlex,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.943535018
p_ni: 0.056464982
Data Source: BioPlex
CYSTM1
Tdark
Novelty: 1.37759108
p_int: 0.800914751
p_ni: 0.002910154
p_wrong: 0.196175096
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.945
Data Source: STRINGDB
CYP2A6
Tchem
Novelty: 0.00105285
Score: 0.941
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.94
Data Source: STRINGDB
CYP1A2
Tchem
Novelty: 0.00034756
Score: 0.939
Data Source: STRINGDB
CYP4A11
Tbio
Novelty: 0.01121493
Score: 0.933
Data Source: STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.09

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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