Tclin CYP3A7 Cytochrome P450 3A7

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Cytochrome P450 3A7

Protein Summary

Description

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P24462
• A4D288
• Q9H241

Gene Name

• CYP3A7

Ensembl ID

• ENST00000336374
• ENSP00000337450
• ENSG00000160870

Symbol

• CYP3A7
• CYPIIIA7
• CYP3A7.1L
• CYP3A7-3AP1
• CYP3A7-CYP3AP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
tissue sample	0.83
kinase perturbation	0.81
PubMedID	0.76
gene perturbation	0.73

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.86   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 216   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.86   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

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1 – 1 of 1

cobicistat

CYP3A7Tclin Enzyme

INHIBITOR Ki: 6.02733421

Pathways (10)

Reactome (5)

KEGG (4)

PathwayCommons (1)

Biological oxidations (R-HSA-211859)

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5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	Cytochrome P450 - arranged by substrate type	65 targets	R-HSA-211897
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Phase I - Functionalization of compounds	105 targets	R-HSA-211945
Reactome	Xenobiotics	24 targets	R-HSA-211981

Name	Explore in Pharos	Explore in Source
Biological oxidations	221 targets	R-HSA-211859
Cytochrome P450 - arranged by substrate type	65 targets	R-HSA-211897
Metabolism	2112 targets	R-HSA-1430728
Phase I - Functionalization of compounds	105 targets	R-HSA-211945
Xenobiotics	24 targets	R-HSA-211981

Gene Ontology Terms (12)

Functions (7)

Components (2)

Processes (3)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
estrogen 16-alpha-hydroxylase activity	Inferred from Direct Assay (IDA)	BHF-UCL
steroid hydroxylase activity	Inferred from Direct Assay (IDA)	BHF-UCL
monooxygenase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
oxygen binding	Traceable Author Statement (TAS)	ProtInc
aromatase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
heme binding	Inferred from Electronic Annotation (IEA)	InterPro
iron ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (75)

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1 – 10 of 75

• See Interactions on String-DB

CYP3A4

Tclin

Family: Enzyme

Novelty: 0.00020884

p_int: 0.999999995

p_wrong: 5e-9

Score: 0.957

Data Source: BioPlex,STRINGDB

CYP3A5

Tclin

Family: Enzyme

Novelty: 0.00135473

p_int: 0.999999926

p_wrong: 7.5e-8

Score: 0.969

Data Source: BioPlex,STRINGDB

VAPB

Tbio

Novelty: 0.00566042

p_int: 0.943535018

p_ni: 0.056464982

Data Source: BioPlex

CYSTM1

Tdark

Novelty: 7

p_int: 0.800914751

p_ni: 0.002910154

p_wrong: 0.196175096

Data Source: BioPlex

CYP1A1

Tchem

Novelty: 0.00028982

Score: 0.945

Data Source: STRINGDB

CYP2A6

Tchem

Novelty: 0.00137727

Score: 0.941

Data Source: STRINGDB

CYP2B6

Tchem

Novelty: 0.00018723

Score: 0.94

Data Source: STRINGDB

CYP1A2

Tchem

Novelty: 0.00045419

Score: 0.939

Data Source: STRINGDB

CYP4A11

Tbio

Novelty: 0.01325821

Score: 0.933

Data Source: STRINGDB

HSD3B2

Tclin

Family: Enzyme

Novelty: 0.00875526

Score: 0.932

Data Source: STRINGDB

Publication Statistics

PubMed Score  93.86

PubMed score by year

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PubTator Score  0.33

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase

GWAS Trait Find Similar Targets

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