Tclin CYP3A7 Cytochrome P450 3A7

Protein Summary

Description

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P24462
• A4D288
• Q9H241

Gene Name

• CYP3A7

Ensembl ID

• ENST00000336374
• ENSP00000337450
• ENSG00000160870

Symbol

• CYP3A7
• CYPIIIA7
• CYP3A7.1L
• CYP3A7-3AP1
• CYP3A7-CYP3AP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
tissue sample	0.83
kinase perturbation	0.81
PubMedID	0.76
gene perturbation	0.73

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Cytochrome P450 3a7

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Cytochrome P450 3a7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.79   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 216   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.79   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1