Protein Classes
Protein Summary
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted th ...more
- ENST00000336374
- ENSP00000337450
- ENSG00000160870
- CYP3A7
- CYPIIIA7
- CYP3A7.1L
- CYP3A7-3AP1
- CYP3A7-CYP3AP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
tissue sample | 0.83 | ||
kinase perturbation | 0.81 | ||
PubMedID | 0.76 | ||
gene perturbation | 0.73 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.09 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 216 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.09 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 216 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 4 | 1 | 4 | 71.8 | |||||
acute coronary syndrome | 1 | 1 | 1 | 64.5 | |||||
ticagrelor measurement | 1 | 1 | 1 | 64.5 | |||||
heel bone mineral density | 2 | 1 | 2 | 40.9 | |||||
estradiol measurement | 1 | 1 | 1 | 29.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 4 | 71.8 | |||||
acute coronary syndrome | 1 | 64.5 | |||||
ticagrelor measurement | 1 | 64.5 | |||||
heel bone mineral density | 2 | 40.9 | |||||
estradiol measurement | 1 | 29.5 | |||||
Pathways (10)
Reactome (5)
KEGG (4)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Metabolism | ||||
Reactome | Phase I - Functionalization of compounds | ||||
Reactome | Xenobiotics | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Metabolism | ||||
Phase I - Functionalization of compounds | ||||
Xenobiotics | ||||
Gene Ontology Terms (12)
Functions (7)
Components (2)
Processes (3)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (75)
1 – 10 of 75
CYP3A4
Family: Enzyme
Novelty: 0.00015515
p_int: 0.999999995
p_wrong: 5e-9
Score: 0.957
Data Source: BioPlex,STRINGDB
CYP3A5
Family: Enzyme
Novelty: 0.00105607
p_int: 0.999999926
p_wrong: 7.5e-8
Score: 0.969
Data Source: BioPlex,STRINGDB
VAPB
Novelty: 0.00542377
p_int: 0.943535018
p_ni: 0.056464982
Data Source: BioPlex
CYSTM1
Novelty: 1.37759108
p_int: 0.800914751
p_ni: 0.002910154
p_wrong: 0.196175096
Data Source: BioPlex
CYP1A1
Novelty: 0.0002404
Score: 0.945
Data Source: STRINGDB
CYP2A6
Novelty: 0.00105285
Score: 0.941
Data Source: STRINGDB
CYP2B6
Novelty: 0.00018351
Score: 0.94
Data Source: STRINGDB
CYP1A2
Novelty: 0.00034756
Score: 0.939
Data Source: STRINGDB
CYP4A11
Novelty: 0.01121493
Score: 0.933
Data Source: STRINGDB
HSD3B2
Family: Enzyme
Novelty: 0.00711552
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score 123.09
PubMed score by year
PubTator Score 0.33
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword