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Tclin
IL4R
Interleukin-4 receptor subunit alpha

Protein Summary
Description
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with a ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
biological process
0.92
disease
0.85
disease perturbation
0.83
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.43   (req: < 5)
Gene RIFs: 188   (req: <= 3)
Antibodies: 564   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.43   (req: >= 5)
Gene RIFs: 188   (req: > 3)
Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dupilumab
no chemical structure image available
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
4
5
93.3
C-reactive protein measurement
1
1
1
90.9
5
6
0
1.1
86.4
childhood onset asthma
2
1
0
1.1
70.6
eosinophil percentage of leukocytes
2
3
3
69
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
93.3
C-reactive protein measurement
1
90.9
0
1.1
86.4
childhood onset asthma
0
1.1
70.6
eosinophil percentage of leukocytes
3
69
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (61)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (181)
1 – 10 of 181
RHBDF2
Tbio
Family: Enzyme
Novelty: 0.02487334
p_int: 0.999108699
p_ni: 0.000858189
p_wrong: 0.000033112
Score: 0.199
Data Source: BioPlex,STRINGDB
ANKLE2
Tbio
Novelty: 0.0995907
p_int: 0.998944033
p_ni: 0.001055967
Data Source: BioPlex
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
p_int: 0.998786542
p_ni: 0.001213458
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
NET1
Tbio
Novelty: 0.13349529
p_int: 0.998712645
p_ni: 0.000007614
p_wrong: 0.001279741
Score: 0.187
Data Source: BioPlex,STRINGDB
PRR11
Tbio
Novelty: 0.05077483
p_int: 0.997696937
p_ni: 0.000924575
p_wrong: 0.001378489
Data Source: BioPlex
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
p_int: 0.997514066
p_ni: 0.002485833
p_wrong: 1.02e-7
Score: 0.945
Data Source: BioPlex,Reactome,STRINGDB
UTP6
Tbio
Novelty: 0.06525007
p_int: 0.995155376
p_ni: 0.003534652
p_wrong: 0.001309972
Data Source: BioPlex
KCNT2
Tchem
Family: IC
Novelty: 0.02412039
p_int: 0.986958517
p_ni: 0.01251286
p_wrong: 0.000528624
Score: 0.359
Data Source: BioPlex,STRINGDB
PKMYT1
Tchem
Family: Kinase
Novelty: 0.03025516
p_int: 0.984216065
p_ni: 0.009716779
p_wrong: 0.006067156
Score: 0.177
Data Source: BioPlex,STRINGDB
STX5
Tbio
Novelty: 0.00964918
p_int: 0.976335336
p_ni: 0.023664664
Data Source: BioPlex
Publication Statistics
PubMed Score  221.43

PubMed score by year
PubTator Score  525.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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