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Tbio
KDELR1
ER lumen protein-retaining receptor 1

Protein Summary
Description
Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike y ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330720
  • ENSP00000329471
  • ENSG00000105438
  • ENST00000597017
  • ENSP00000470841

Symbol
  • ERD2.1
  • ERD2
  • HDEL
  • PM23
  • ERD2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
hub protein
0.82
gene perturbation
0.71
virus perturbation
0.68
cellular component
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.53   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.53   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (233)
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.999771813
p_ni:  0.000228187
Score:  0.273
Data Source:  BioPlex,STRINGDB
UBL7
Tdark
Novelty:  0.20935024
p_int:  0.997184229
p_ni:  0.002763745
p_wrong:  0.000052026
Score:  0.178
Data Source:  BioPlex,STRINGDB
MINDY1
Tbio
Novelty:  0.31540765
p_int:  0.994367783
p_ni:  0.002025076
p_wrong:  0.003607141
Score:  0.182
Data Source:  BioPlex,STRINGDB
VPS36
Tbio
Novelty:  0.03382542
p_int:  0.993252316
p_ni:  0.002436212
p_wrong:  0.004311471
Score:  0.208
Data Source:  BioPlex,STRINGDB
TAX1BP1
Tbio
Novelty:  0.02498501
p_int:  0.975167507
p_ni:  0.024832493
Score:  0.305
Data Source:  BioPlex,STRINGDB
TRAFD1
Tbio
Novelty:  0.144593
p_int:  0.960967979
p_ni:  0.039032021
Data Source:  BioPlex
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.941342115
p_ni:  0.058657885
Score:  0.647
Data Source:  BioPlex,STRINGDB
PSMD11
Tbio
Family:  Enzyme
Novelty:  0.02148951
p_int:  0.914453437
p_ni:  0.085546563
Score:  0.349
Data Source:  BioPlex,STRINGDB
UBQLN4
Tbio
Novelty:  0.0428679
p_int:  0.90229784
p_ni:  0.09770216
Score:  0.358
Data Source:  BioPlex,STRINGDB
NPLOC4
Tbio
Novelty:  0.01690434
p_int:  0.898348719
p_ni:  0.101651281
Score:  0.218
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915387
68137
Horse
KDEL endoplasmic reticulum protein retention receptor 1
VGNC:51044
100050944
Cow
KDEL endoplasmic reticulum protein retention receptor 1
VGNC:52202
618184
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
KDEL endoplasmic reticulum protein retention receptor 1
Cow
KDEL endoplasmic reticulum protein retention receptor 1
Publication Statistics
PubMed Score 279.53
PubMed score by year
PubTator Score 101.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title