Tbio KDELR1 ER lumen protein-retaining receptor 1

Protein Summary

Description

Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P24390
• B2R6N4
• Q54A39
• Q8NBW7

Gene Name

• KDELR1

Ensembl ID

• ENST00000330720
• ENSP00000329471
• ENSG00000105438
• ENST00000597017
• ENSP00000470841

Symbol

• ERD2.1
• ERD2
• HDEL
• PM23
• ERD2.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
hub protein	0.82
gene perturbation	0.71
virus perturbation	0.68
cellular component	0.64

Protein Classes

PANTHER Classes

Protein / Receptor / Er Lumen Protein-retaining Receptor 1

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Er Lumen Protein-retaining Receptor 1

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Er Lumen Protein-retaining Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.84   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.84   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0