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Tbio
CRHBP
Corticotropin-releasing factor-binding protein

Protein Summary
Description
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274368
  • ENSP00000274368
  • ENSG00000145708

Symbol
  • CRFBP
  • CRFBP
  • CRF-BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
cell type or tissue
0.79
PubMedID
0.71
disease
0.59
tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.76   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.76   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (52)
1 – 10 of 52
TNIP1
Tbio
Novelty:  0.0147254
p_int:  0.999999937
p_ni:  6.3e-8
Score:  0.261
Data Source:  BioPlex,STRINGDB
CCNB2
Tbio
Novelty:  0.00672914
p_int:  0.999998711
p_ni:  0.000001289
Score:  0.196
Data Source:  BioPlex,STRINGDB
PHLDB3
Tdark
Novelty:  2.01921901
p_int:  0.999062182
p_ni:  0.000937818
Score:  0.183
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.998984074
p_ni:  0.001015926
Data Source:  BioPlex
COA7
Tbio
Family:  Enzyme
Novelty:  0.08512811
p_int:  0.927001863
p_ni:  0.072998137
Score:  0.513
Data Source:  BioPlex,STRINGDB
SQSTM1
Tbio
Novelty:  0.00100555
p_int:  0.918765524
p_ni:  0.081234476
Score:  0.219
Data Source:  BioPlex,STRINGDB
IMPACT
Tbio
Novelty:  0.05823777
p_int:  0.914563691
p_ni:  0.009277685
p_wrong:  0.076158624
Score:  0.297
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.878350508
p_ni:  0.121649492
Data Source:  BioPlex
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.874909249
p_ni:  0.12509074
p_wrong:  1.1e-8
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.786569331
p_ni:  0.213430669
Data Source:  BioPlex
Pathways (5)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (39)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
corticotropin releasing hormone binding protein
VGNC:3956
461799
Macaque
corticotropin releasing hormone binding protein
707589
Mouse
MGI:88497
12919
Rat
RGD:2403
29625
Dog
corticotropin releasing hormone binding protein
VGNC:39610
610584
Species
Name
OMA
EggNOG
Inparanoid
Chimp
corticotropin releasing hormone binding protein
Macaque
corticotropin releasing hormone binding protein
Mouse
Rat
Dog
corticotropin releasing hormone binding protein
Publication Statistics
PubMed Score 166.76
PubMed score by year
PubTator Score 119.47
PubTator score by year