Protein Classes
Protein Summary
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. The protein encoded by this gene belongs to the ...more
- ENST00000227507
- ENSP00000227507
- ENSG00000110092
- BCL1
- PRAD1
- BCL1
- PRAD1
- U21B31
- D11S287E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
transcription factor perturbation | 1 | ||
biological term | 0.99 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7524 (req: < 5)
Gene RIFs: 1176 (req: <= 3)
Antibodies: 1839 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7524 (req: >= 5)
Gene RIFs: 1176 (req: > 3)
Antibodies: 1839 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 50
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 1 | 1.1 | 93.8 | |||||
AL amyloidosis | 5 | 1 | 0 | 1.4 | 71.8 | ||||
1 | 1 | 0 | 1.9 | 70.7 | |||||
IgG isotype profile measurement | 3 | 1 | 0 | 1.6 | 67.2 | ||||
heart amyloid deposition measurement | 1 | 1 | 0 | 1.4 | 38.1 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.1 | 93.8 | |||||
AL amyloidosis | 0 | 1.4 | 71.8 | ||||
0 | 1.9 | 70.7 | |||||
IgG isotype profile measurement | 0 | 1.6 | 67.2 | ||||
heart amyloid deposition measurement | 0 | 1.4 | 38.1 | ||||
Orthologs (9)
Protein Structure (5 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (216)
Reactome (39)
KEGG (46)
PathwayCommons (24)
WikiPathways (107)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 39
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Cyclin A:Cdk2-associated events at S phase entry | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Cyclin A:Cdk2-associated events at S phase entry | ||||
Gene Ontology Terms (59)
Functions (9)
Components (9)
Processes (41)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (847)
1 – 10 of 847
CDKN1B
Family: Enzyme
Novelty: 0.00069449
p_int: 0.99999993
p_ni: 7e-8
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
CDKN1C
Family: Enzyme
Novelty: 0.00220485
p_int: 0.999999617
p_ni: 3.82e-7
p_wrong: 1e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
CDKN1A
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999998862
p_ni: 0.000001135
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDKN2C
Family: Enzyme
Novelty: 0.00806886
p_int: 0.999966718
p_ni: 0.000033279
p_wrong: 3e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
TCHH
Novelty: 0.00303837
p_int: 0.999778397
p_ni: 0.00004013
p_wrong: 0.000181473
Score: 0.233
Data Source: BioPlex,STRINGDB
CDK5
Family: Kinase
Novelty: 0.00071394
p_int: 0.998468706
p_ni: 0.001531294
Score: 0.748
Data Source: BioPlex,STRINGDB
CDK2
Family: Kinase
Novelty: 0.00032118
p_int: 0.993217704
p_ni: 0.006782296
Score: 0.999
Data Source: BioPlex,STRINGDB
TSR3
Novelty: 0.09337944
p_int: 0.938940283
p_ni: 0.061059717
Data Source: BioPlex
CDK1
Family: Kinase
Novelty: 0.00040776
p_int: 0.83998219
p_ni: 0.16001781
Score: 0.985
Data Source: BioPlex,STRINGDB
CDK4
Family: Kinase
Novelty: 0.00036742
p_int: 0.750000029
p_ni: 0.249999971
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score 7524.00
PubMed score by year
PubTator Score 6284.81
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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