Protein Summary
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. The protein encoded by this gene belongs to the ...more
- ENST00000227507
- ENSP00000227507
- ENSG00000110092
- BCL1
- PRAD1
- BCL1
- PRAD1
- U21B31
- D11S287E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
transcription factor perturbation | 1 | ||
biological term | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7678.22 (req: < 5)
Gene RIFs: 1176 (req: <= 3)
Antibodies: 1839 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7678.22 (req: >= 5)
Gene RIFs: 1176 (req: > 3)
Antibodies: 1839 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 50
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (847)
CDKN1B
Family: Enzyme
Novelty: 0.00069449
p_int: 0.99999993
p_ni: 7e-8
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
CDKN1C
Family: Enzyme
Novelty: 0.00220485
p_int: 0.999999617
p_ni: 3.82e-7
p_wrong: 1e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
CDKN1A
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999998862
p_ni: 0.000001135
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDKN2C
Family: Enzyme
Novelty: 0.00806886
p_int: 0.999966718
p_ni: 0.000033279
p_wrong: 3e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
TCHH
Novelty: 0.00303837
p_int: 0.999778397
p_ni: 0.00004013
p_wrong: 0.000181473
Score: 0.233
Data Source: BioPlex,STRINGDB
CDK5
Family: Kinase
Novelty: 0.00071394
p_int: 0.998468706
p_ni: 0.001531294
Score: 0.748
Data Source: BioPlex,STRINGDB
CDK2
Family: Kinase
Novelty: 0.00032118
p_int: 0.993217704
p_ni: 0.006782296
Score: 0.999
Data Source: BioPlex,STRINGDB
CDK1
Family: Kinase
Novelty: 0.00040776
p_int: 0.83998219
p_ni: 0.16001781
Score: 0.985
Data Source: BioPlex,STRINGDB
CDK4
Family: Kinase
Novelty: 0.00036742
p_int: 0.750000029
p_ni: 0.249999971
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (7)
Upstream (5)
Downstream (2)
1 – 5 of 5
Pathways (216)
Reactome (39)
KEGG (46)
PathwayCommons (24)
WikiPathways (107)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Cyclin A:Cdk2-associated events at S phase entry | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Cyclin A:Cdk2-associated events at S phase entry | ||||
Viral Interactions (0)
Gene Ontology Terms (59)
Functions (9)
Components (9)
Processes (41)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
4 | 4 | 2 | 1.1 | 91.2 | |||||
2 | 2 | 0 | 1.3 | 85.3 | |||||
BMI-adjusted hip circumference | 1 | 2 | 2 | 64.8 | |||||
IgG isotype profile measurement | 3 | 1 | 0 | 1.6 | 54.4 | ||||
AL amyloidosis | 5 | 1 | 0 | 1.4 | 54.4 | ||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
2 | 1.1 | 91.2 | |||||
0 | 1.3 | 85.3 | |||||
BMI-adjusted hip circumference | 2 | 64.8 | |||||
IgG isotype profile measurement | 0 | 1.6 | 54.4 | ||||
AL amyloidosis | 0 | 1.4 | 54.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | cyclin D1 | 574320 | ||||||
Mouse | MGI:88313 | 12443 | ||||||
Rat | RGD:68384 | 58919 | ||||||
Dog | cyclin D1 | VGNC:54266 | 449028 | |||||
Cow | cyclin D1 | VGNC:26962 | 524530 | |||||
Publication Statistics
PubMed Score 7678.22
PubMed score by year
PubTator Score 6284.81
PubTator score by year
Related Publications
Text Mined References (1361)
GeneRif Annotations (1176)
Items per page:
0 of 0
PMID | Year | Title |
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