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Tchem
CCND1
G1/S-specific cyclin-D1

Protein Summary
Description
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. The protein encoded by this gene belongs to the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227507
  • ENSP00000227507
  • ENSG00000110092

Symbol
  • BCL1
  • PRAD1
  • BCL1
  • PRAD1
  • U21B31
  • D11S287E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
transcription factor perturbation
1
biological term
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7524   (req: < 5)
Gene RIFs: 1176   (req: <= 3)
Antibodies: 1839   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7524   (req: >= 5)
Gene RIFs: 1176   (req: > 3)
Antibodies: 1839   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
palbociclib
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.1
93.8
AL amyloidosis
5
1
0
1.4
71.8
1
1
0
1.9
70.7
IgG isotype profile measurement
3
1
0
1.6
67.2
heart amyloid deposition measurement
1
1
0
1.4
38.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
93.8
AL amyloidosis
0
1.4
71.8
0
1.9
70.7
IgG isotype profile measurement
0
1.6
67.2
heart amyloid deposition measurement
0
1.4
38.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cyclin D1
574320
Mouse
MGI:88313
12443
Rat
RGD:68384
58919
Dog
cyclin D1
VGNC:54266
449028
Cow
cyclin D1
VGNC:26962
524530
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cyclin D1
Mouse
Rat
Dog
cyclin D1
Cow
cyclin D1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P24385-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (216)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Chromatin modifying enzymes
Chromatin organization
Cyclin A:Cdk2-associated events at S phase entry
Gene Ontology Terms (59)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (847)
1 – 10 of 847
CDKN1B
Tbio
Family: Enzyme
Novelty: 0.00069449
p_int: 0.99999993
p_ni: 7e-8
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
CDKN1C
Tbio
Family: Enzyme
Novelty: 0.00220485
p_int: 0.999999617
p_ni: 3.82e-7
p_wrong: 1e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999998862
p_ni: 0.000001135
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDKN2C
Tbio
Family: Enzyme
Novelty: 0.00806886
p_int: 0.999966718
p_ni: 0.000033279
p_wrong: 3e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
TCHH
Tbio
Novelty: 0.00303837
p_int: 0.999778397
p_ni: 0.00004013
p_wrong: 0.000181473
Score: 0.233
Data Source: BioPlex,STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
p_int: 0.998468706
p_ni: 0.001531294
Score: 0.748
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.993217704
p_ni: 0.006782296
Score: 0.999
Data Source: BioPlex,STRINGDB
TSR3
Tdark
Novelty: 0.09337944
p_int: 0.938940283
p_ni: 0.061059717
Data Source: BioPlex
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
p_int: 0.83998219
p_ni: 0.16001781
Score: 0.985
Data Source: BioPlex,STRINGDB
CDK4
Tclin
Family: Kinase
Novelty: 0.00036742
p_int: 0.750000029
p_ni: 0.249999971
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  7524.00

PubMed score by year
PubTator Score  6284.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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