Tchem MMP11 Stromelysin-3

Protein Summary

Description

May play an important role in the progression of epithelial malignancies. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P24347
• Q5FX24
• Q6PEZ6
• Q9UC26
• SL-3

Gene Name

• MMP11

Ensembl ID

• ENST00000215743
• ENSP00000215743
• ENSG00000099953
• ENST00000612388
• ENSP00000483349
• ENSG00000275365

Symbol

• STMY3
• ST3
• SL-3
• STMY3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.95
gene perturbation	0.82
kinase perturbation	0.71
transcription factor	0.63

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.34   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 499   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.34   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 499   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Active Ligands (4)

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1 – 4 of 4

CHEMBL447457

MMP11Tchem

pKi : 9.64

CHEMBL115774

MMP11Tchem

pKi : 8.3

CHEMBL2153737

MMP11Tchem

pKi : 8.3

CHEMBL2153738

MMP11Tchem

pKi : 6.39

Protein-Protein Interactions (75)

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1 – 10 of 75

• See Interactions on String-DB

FURIN

Tchem

Family:  Enzyme

Novelty:  0.00055079

Score:  0.942

Data Source:  Reactome,STRINGDB

MMP2

Tchem

Family:  Enzyme

Novelty:  0.00012762

Score:  0.923

Data Source:  STRINGDB

MMP7

Tchem

Family:  Enzyme

Novelty:  0.00080093

Score:  0.915

Data Source:  STRINGDB

MMP1

Tchem

Family:  Enzyme

Novelty:  0.00030922

Score:  0.913

Data Source:  STRINGDB

A2M

Tbio

Novelty:  0.00070446

Score:  0.903

Data Source:  STRINGDB

TIMP2

Tbio

Family:  Enzyme

Novelty:  0.00064016

Score:  0.77

Data Source:  STRINGDB

ST5

Tbio

Novelty:  0.0046113

Score:  0.737

Data Source:  STRINGDB

CRYBG1

Tbio

Novelty:  0.05471025

Score:  0.727

Data Source:  STRINGDB

SDCBP

Tbio

Novelty:  0.00242211

Score:  0.703

Data Source:  STRINGDB

TIMP1

Tbio

Family:  Enzyme

Novelty:  0.00020986

Score:  0.693

Data Source:  STRINGDB

Pathways (6)

Reactome (4)

WikiPathways (2)

Activation of Matrix Metalloproteinases (R-HSA-1592389)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Reactome	Collagen degradation	40 targets	R-HSA-1442490
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Collagen degradation	40 targets	R-HSA-1442490
Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Extracellular matrix organization	297 targets	R-HSA-1474244

Gene Ontology Terms (14)

Functions (4)

Components (3)

Processes (7)

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1 – 4 of 4

GO Term	Evidence	Assigned by
metallopeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metalloendopeptidase activity	Traceable Author Statement (TAS)	Reactome
serine-type endopeptidase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

GWAS Traits (30)

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5

1 – 5 of 30

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum IgG glycosylation measurement	EFO_0005193	ENSG00000275365	1	1	1		82.8
serum IgG glycosylation measurement	EFO_0005193	ENSG00000099953	1	1	1		82.8
serum non-albumin protein measurement	EFO_0004568	ENSG00000275365	1	2	2		76.7
serum non-albumin protein measurement	EFO_0004568	ENSG00000099953	1	2	2		76.7
hypertrophic cardiomyopathy	EFO_0000538	ENSG00000275365	2	1	0	1.3	67.9

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1 – 5 of 30

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum IgG glycosylation measurement	EFO_0005193	1		82.8
serum IgG glycosylation measurement	EFO_0005193	1		82.8
serum non-albumin protein measurement	EFO_0004568	2		76.7
serum non-albumin protein measurement	EFO_0004568	2		76.7
hypertrophic cardiomyopathy	EFO_0000538	0	1.3	67.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Cleavage on pair of basic residues
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Hydrolase
Metal-binding
Metalloprotease

GWAS Trait Find Similar Targets

No Header	No Header
body height
dilated cardiomyopathy
ejection fraction measurement
electrocardiography
fractional shortening
heart function measurement
hypertrophic cardiomyopathy
Left ventricular mass to end-diastolic volume ratio
left ventricular structural measurement
left ventricular systolic function measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
homeostasis/metabolism phenotype
integument phenotype
limbs/digits/tail phenotype
neoplasm

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	matrix metallopeptidase 11	VGNC:53402	458701
Macaque	matrix metallopeptidase 11		699067
Mouse	matrix metallopeptidase 11	MGI:97008	17385
Rat	matrix metallopeptidase 11	RGD:3099	25481
Dog	matrix metallopeptidase 11	VGNC:43274	486408

Species	Name	OMA	EggNOG	Inparanoid
Chimp	matrix metallopeptidase 11
Macaque	matrix metallopeptidase 11
Mouse	matrix metallopeptidase 11
Rat	matrix metallopeptidase 11
Dog	matrix metallopeptidase 11

Publication Statistics

PubMed Score 670.34

PubMed score by year

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PubTator Score 248.79

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