Protein Summary
May play an important role in the progression of epithelial malignancies. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
- ENST00000215743
- ENSP00000215743
- ENSG00000099953
- ENST00000612388
- ENSP00000483349
- ENSG00000275365
- STMY3
- ST3
- SL-3
- STMY3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
PubMedID | 0.95 | ||
gene perturbation | 0.82 | ||
kinase perturbation | 0.71 | ||
transcription factor | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 670.34 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 499 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 670.34 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 499 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (75)
Nearest Tclin Targets
Pathways (6)
Reactome (4)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Collagen degradation | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Collagen degradation | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
serum IgG glycosylation measurement | 1 | 1 | 1 | 82.8 | ||||||
serum IgG glycosylation measurement | 1 | 1 | 1 | 82.8 | ||||||
serum non-albumin protein measurement | 1 | 2 | 2 | 76.7 | ||||||
serum non-albumin protein measurement | 1 | 2 | 2 | 76.7 | ||||||
2 | 1 | 0 | 1.3 | 67.9 | ||||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum IgG glycosylation measurement | 1 | 82.8 | |||||
serum IgG glycosylation measurement | 1 | 82.8 | |||||
serum non-albumin protein measurement | 2 | 76.7 | |||||
serum non-albumin protein measurement | 2 | 76.7 | |||||
0 | 1.3 | 67.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 11 | VGNC:53402 | 458701 | |||||
Macaque | matrix metallopeptidase 11 | 699067 | ||||||
Mouse | MGI:97008 | 17385 | ||||||
Rat | RGD:3099 | 25481 | ||||||
Dog | matrix metallopeptidase 11 | VGNC:43274 | 486408 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 11 | |||||
Macaque | matrix metallopeptidase 11 | |||||
Mouse | ||||||
Rat | ||||||
Dog | matrix metallopeptidase 11 | |||||
Publication Statistics
PubMed Score 670.34
PubMed score by year
PubTator Score 248.79
PubTator score by year
Related Publications
Text Mined References (75)
GeneRif Annotations (60)
Items per page:
0 of 0
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