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Tchem
PRTN3
Myeloblastin

Protein Summary
Description
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234347
  • ENSP00000234347
  • ENSG00000196415
  • ENST00000612112
  • ENSP00000478977
  • ENSG00000277804

Symbol
  • MBN
  • MBN
  • MBT
  • NP4
  • P29
  • PR3
  • ACPA
  • AGP7
  • NP-4
  • PR-3
  • CANCA
  • C-ANCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.81
gene perturbation
0.81
cellular component
0.8
cell type or tissue
0.76
disease
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4704.34   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 478   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4704.34   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 478   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (19)
compound 4g [PMID: 22595175]
Rendered image for compound 4g [PMID: 22595175]
CHEMBL4557877
Rendered image for CHEMBL4557877
CHEMBL4560512
Rendered image for CHEMBL4560512
CHEMBL4455694
Rendered image for CHEMBL4455694
CHEMBL3398148
Rendered image for CHEMBL3398148
US9073833, 5
Rendered image for US9073833, 5
Protein-Protein Interactions (203)
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.999956852
p_ni:  0.000043148
Data Source:  BioPlex
FBXO21
Tbio
Novelty:  0.2186203
p_int:  0.999767895
p_ni:  0.000232105
Data Source:  BioPlex
GOLIM4
Tbio
Novelty:  0.01923513
p_int:  0.999747494
p_ni:  0.000252505
p_wrong:  1e-9
Data Source:  BioPlex
SERPINB1
Tbio
Family:  Enzyme
Novelty:  0.00267786
p_int:  0.981843281
p_ni:  0.017744273
p_wrong:  0.000412446
Score:  0.755
Data Source:  BioPlex,STRINGDB
RAB3GAP1
Tbio
Family:  Enzyme
Novelty:  0.0286836
p_int:  0.978256955
p_ni:  0.021743012
p_wrong:  3.3e-8
Data Source:  BioPlex
SPCS1
Tbio
Family:  Enzyme
Novelty:  0.0731223
p_int:  0.976080227
p_ni:  0.005873529
p_wrong:  0.018046244
Data Source:  BioPlex
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.941731489
p_ni:  0.058268472
p_wrong:  3.8e-8
Data Source:  BioPlex
QRICH1
Tdark
Novelty:  0.27714699
p_int:  0.88343682
p_ni:  0.114446273
p_wrong:  0.002116907
Data Source:  BioPlex
SPCS2
Tdark
Family:  Enzyme
Novelty:  0.21358992
p_int:  0.859166522
p_ni:  0.140833478
Data Source:  BioPlex
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
p_int:  0.834817607
p_ni:  0.165181977
p_wrong:  4.16e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Cytokine Signaling in Immune system
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Common Pathway of Fibrin Clot Formation
Cytokine Signaling in Immune system
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
13
20
99.5
reticulocyte count
7
10
28
99.3
heel bone mineral density
3
4
6
94.5
serum gamma-glutamyl transferase measurement
2
2
3
93.1
hematocrit
2
2
3
93.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
20
99.5
reticulocyte count
28
99.3
heel bone mineral density
6
94.5
serum gamma-glutamyl transferase measurement
3
93.1
hematocrit
3
93.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteinase 3
749895
Mouse
MGI:893580
19152
Rat
RGD:1304898
314615
Horse
proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495]
Cow
proteinase 3
VGNC:33427
100298591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteinase 3
Mouse
Rat
Horse
proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495]
Cow
proteinase 3
Publication Statistics
PubMed Score 4704.34
PubMed score by year
PubTator Score 2361.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title