You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FCAR
Immunoglobulin alpha Fc receptor

Protein Summary
Description
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345937
  • ENSP00000338257
  • ENSG00000186431
  • ENST00000353758
  • ENSP00000338058
  • ENST00000355524
  • ENSP00000347714
  • ENST00000359272
  • ENSP00000352218
  • ENST00000391723
  • ENSP00000375603
  • ENST00000391724
  • ENSP00000375604
  • ENST00000391725
  • ENSP00000375605
  • ENST00000391726
  • ENSP00000375606
  • ENST00000469767
  • ENSP00000473814
  • ENST00000488066
  • ENSP00000474512
  • ENST00000610340
  • ENSP00000477610
  • ENSG00000275136
  • ENST00000610397
  • ENSP00000480965
  • ENSG00000275269
  • ENST00000610786
  • ENSP00000483121
  • ENSG00000276858
  • ENST00000611018
  • ENSP00000484483
  • ENSG00000275970
  • ENST00000611130
  • ENSP00000484917
  • ENSG00000273738
  • ENST00000611871
  • ENSP00000482976
  • ENST00000611943
  • ENSP00000482273
  • ENSG00000275564
  • ENST00000612150
  • ENSP00000478233
  • ENST00000612159
  • ENSP00000484662
  • ENSG00000276985
  • ENST00000612505
  • ENSP00000479792
  • ENST00000612803
  • ENSP00000478454
  • ENST00000612815
  • ENSP00000483503
  • ENST00000612918
  • ENSP00000482056
  • ENSG00000274580
  • ENST00000613199
  • ENSP00000478465
  • ENST00000613201
  • ENSP00000482108
  • ENST00000613298
  • ENSP00000482451
  • ENST00000613318
  • ENSP00000481560
  • ENST00000613663
  • ENSP00000483437
  • ENST00000613685
  • ENSP00000481230
  • ENST00000614226
  • ENSP00000483099
  • ENST00000614298
  • ENSP00000483472
  • ENST00000614433
  • ENSP00000480748
  • ENST00000614689
  • ENSP00000480013
  • ENST00000614893
  • ENSP00000477966
  • ENST00000614917
  • ENSP00000479831
  • ENST00000614954
  • ENSP00000479924
  • ENST00000615040
  • ENSP00000477656
  • ENST00000615110
  • ENSP00000484276
  • ENST00000615361
  • ENSP00000482741
  • ENST00000615703
  • ENSP00000484868
  • ENST00000615719
  • ENSP00000482518
  • ENST00000615800
  • ENSP00000483841
  • ENST00000615829
  • ENSP00000482623
  • ENST00000615937
  • ENSP00000478075
  • ENST00000616340
  • ENSP00000481676
  • ENST00000616878
  • ENSP00000480970
  • ENST00000616969
  • ENSP00000479039
  • ENST00000617025
  • ENSP00000481129
  • ENST00000617609
  • ENSP00000481394
  • ENST00000617696
  • ENSP00000482670
  • ENST00000617762
  • ENSP00000484136
  • ENST00000617766
  • ENSP00000479230
  • ENST00000617778
  • ENSP00000480498
  • ENST00000617964
  • ENSP00000484141
  • ENST00000618271
  • ENSP00000484741
  • ENST00000618287
  • ENSP00000481668
  • ENST00000618328
  • ENSP00000480496
  • ENST00000618658
  • ENSP00000479688
  • ENST00000618805
  • ENSP00000481985
  • ENST00000618985
  • ENSP00000480323
  • ENST00000619073
  • ENSP00000479360
  • ENST00000619155
  • ENSP00000480461
  • ENST00000619385
  • ENSP00000482334
  • ENST00000619414
  • ENSP00000478163
  • ENST00000619822
  • ENSP00000483250
  • ENST00000620162
  • ENSP00000483258
  • ENST00000620179
  • ENSP00000478315
  • ENSG00000278415
  • ENST00000620270
  • ENSP00000482022
  • ENST00000620397
  • ENSP00000477584
  • ENST00000620801
  • ENSP00000481195
  • ENST00000620822
  • ENSP00000483327
  • ENST00000620873
  • ENSP00000479099
  • ENST00000621004
  • ENSP00000484816
  • ENST00000621009
  • ENSP00000482025
  • ENST00000621289
  • ENSP00000481366
  • ENST00000621417
  • ENSP00000478634
  • ENST00000621684
  • ENSP00000479239
  • ENST00000621702
  • ENSP00000482807
  • ENST00000621755
  • ENSP00000484906
  • ENST00000621882
  • ENSP00000484272
  • ENST00000622157
  • ENSP00000481502
  • ENST00000622470
  • ENSP00000477673
  • ENST00000622491
  • ENSP00000477643
  • ENST00000622543
  • ENSP00000483402
  • ENST00000622646
  • ENSP00000480406
  • ENST00000622737
  • ENSP00000479738
  • ENST00000622777
  • ENSP00000481345
  • ENST00000622883
  • ENSP00000479880
  • ENST00000622904
  • ENSP00000480444
  • ENST00000638206
  • ENSP00000492749
  • ENSG00000284061
  • ENST00000638212
  • ENSP00000492230
  • ENST00000638238
  • ENSP00000492629
  • ENSG00000283750
  • ENST00000638242
  • ENSP00000492364
  • ENST00000638244
  • ENSP00000492699
  • ENSG00000283953
  • ENST00000638285
  • ENSP00000491595
  • ENST00000638290
  • ENSP00000492003
  • ENST00000638453
  • ENSP00000491493
  • ENST00000638527
  • ENSP00000491362
  • ENSG00000284245
  • ENST00000638553
  • ENSP00000491372
  • ENSG00000284004
  • ENST00000638625
  • ENSP00000492755
  • ENST00000638882
  • ENSP00000492226
  • ENST00000638900
  • ENSP00000491778
  • ENST00000638906
  • ENSP00000492268
  • ENST00000638945
  • ENSP00000492228
  • ENST00000638966
  • ENSP00000491307
  • ENST00000638995
  • ENSP00000491741
  • ENST00000639014
  • ENSP00000491039
  • ENST00000639163
  • ENSP00000491556
  • ENST00000639178
  • ENSP00000492137
  • ENST00000639193
  • ENSP00000491447
  • ENST00000639223
  • ENSP00000492274
  • ENST00000639337
  • ENSP00000491914
  • ENST00000639392
  • ENSP00000492068
  • ENST00000639402
  • ENSP00000492442
  • ENST00000639426
  • ENSP00000492415
  • ENST00000639428
  • ENSP00000491642
  • ENST00000639455
  • ENSP00000491849
  • ENST00000639575
  • ENSP00000492321
  • ENST00000639763
  • ENSP00000491420
  • ENST00000640025
  • ENSP00000492529
  • ENST00000640032
  • ENSP00000492077
  • ENST00000640047
  • ENSP00000490997
  • ENST00000640063
  • ENSP00000491889
  • ENST00000640070
  • ENSP00000491192
  • ENST00000640239
  • ENSP00000492762
  • ENST00000640405
  • ENSP00000491490
  • ENST00000640415
  • ENSP00000491274
  • ENST00000640430
  • ENSP00000492494
  • ENST00000640462
  • ENSP00000491298
  • ENST00000640562
  • ENSP00000492074
  • ENST00000640582
  • ENSP00000492447
  • ENST00000640584
  • ENSP00000491818
  • ENST00000640618
  • ENSP00000491815
  • ENST00000640687
  • ENSP00000492597
  • ENST00000640761
  • ENSP00000492411
  • ENST00000640811
  • ENSP00000492678
  • ENST00000640878
  • ENSP00000492686
  • ENST00000640908
  • ENSP00000492162
  • ENST00000640918
  • ENSP00000491746

Symbol
  • CD89
  • CD89
  • FcalphaRI
  • CTB-61M7.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
microRNA
0.6
cell type or tissue
0.58
biological term
0.57
cell line
0.54


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.76   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 593   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.76   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 593   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0