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Tbio
FCAR
Immunoglobulin alpha Fc receptor

Protein Classes
Protein Summary
Description
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345937
  • ENSP00000338257
  • ENSG00000186431
  • ENST00000353758
  • ENSP00000338058
  • ENST00000355524
  • ENSP00000347714
  • ENST00000359272
  • ENSP00000352218
  • ENST00000391723
  • ENSP00000375603
  • ENST00000391724
  • ENSP00000375604
  • ENST00000391725
  • ENSP00000375605
  • ENST00000391726
  • ENSP00000375606
  • ENST00000469767
  • ENSP00000473814
  • ENST00000488066
  • ENSP00000474512
  • ENST00000610340
  • ENSP00000477610
  • ENSG00000275136
  • ENST00000610397
  • ENSP00000480965
  • ENSG00000275269
  • ENST00000610786
  • ENSP00000483121
  • ENSG00000276858
  • ENST00000611018
  • ENSP00000484483
  • ENSG00000275970
  • ENST00000611130
  • ENSP00000484917
  • ENSG00000273738
  • ENST00000611871
  • ENSP00000482976
  • ENST00000611943
  • ENSP00000482273
  • ENSG00000275564
  • ENST00000612150
  • ENSP00000478233
  • ENST00000612159
  • ENSP00000484662
  • ENSG00000276985
  • ENST00000612505
  • ENSP00000479792
  • ENST00000612803
  • ENSP00000478454
  • ENST00000612815
  • ENSP00000483503
  • ENST00000612918
  • ENSP00000482056
  • ENSG00000274580
  • ENST00000613199
  • ENSP00000478465
  • ENST00000613201
  • ENSP00000482108
  • ENST00000613298
  • ENSP00000482451
  • ENST00000613318
  • ENSP00000481560
  • ENST00000613663
  • ENSP00000483437
  • ENST00000613685
  • ENSP00000481230
  • ENST00000614226
  • ENSP00000483099
  • ENST00000614298
  • ENSP00000483472
  • ENST00000614433
  • ENSP00000480748
  • ENST00000614689
  • ENSP00000480013
  • ENST00000614893
  • ENSP00000477966
  • ENST00000614917
  • ENSP00000479831
  • ENST00000614954
  • ENSP00000479924
  • ENST00000615040
  • ENSP00000477656
  • ENST00000615110
  • ENSP00000484276
  • ENST00000615361
  • ENSP00000482741
  • ENST00000615703
  • ENSP00000484868
  • ENST00000615719
  • ENSP00000482518
  • ENST00000615800
  • ENSP00000483841
  • ENST00000615829
  • ENSP00000482623
  • ENST00000615937
  • ENSP00000478075
  • ENST00000616340
  • ENSP00000481676
  • ENST00000616878
  • ENSP00000480970
  • ENST00000616969
  • ENSP00000479039
  • ENST00000617025
  • ENSP00000481129
  • ENST00000617609
  • ENSP00000481394
  • ENST00000617696
  • ENSP00000482670
  • ENST00000617762
  • ENSP00000484136
  • ENST00000617766
  • ENSP00000479230
  • ENST00000617778
  • ENSP00000480498
  • ENST00000617964
  • ENSP00000484141
  • ENST00000618271
  • ENSP00000484741
  • ENST00000618287
  • ENSP00000481668
  • ENST00000618328
  • ENSP00000480496
  • ENST00000618658
  • ENSP00000479688
  • ENST00000618805
  • ENSP00000481985
  • ENST00000618985
  • ENSP00000480323
  • ENST00000619073
  • ENSP00000479360
  • ENST00000619155
  • ENSP00000480461
  • ENST00000619385
  • ENSP00000482334
  • ENST00000619414
  • ENSP00000478163
  • ENST00000619822
  • ENSP00000483250
  • ENST00000620162
  • ENSP00000483258
  • ENST00000620179
  • ENSP00000478315
  • ENSG00000278415
  • ENST00000620270
  • ENSP00000482022
  • ENST00000620397
  • ENSP00000477584
  • ENST00000620801
  • ENSP00000481195
  • ENST00000620822
  • ENSP00000483327
  • ENST00000620873
  • ENSP00000479099
  • ENST00000621004
  • ENSP00000484816
  • ENST00000621009
  • ENSP00000482025
  • ENST00000621289
  • ENSP00000481366
  • ENST00000621417
  • ENSP00000478634
  • ENST00000621684
  • ENSP00000479239
  • ENST00000621702
  • ENSP00000482807
  • ENST00000621755
  • ENSP00000484906
  • ENST00000621882
  • ENSP00000484272
  • ENST00000622157
  • ENSP00000481502
  • ENST00000622470
  • ENSP00000477673
  • ENST00000622491
  • ENSP00000477643
  • ENST00000622543
  • ENSP00000483402
  • ENST00000622646
  • ENSP00000480406
  • ENST00000622737
  • ENSP00000479738
  • ENST00000622777
  • ENSP00000481345
  • ENST00000622883
  • ENSP00000479880
  • ENST00000622904
  • ENSP00000480444
  • ENST00000638206
  • ENSP00000492749
  • ENSG00000284061
  • ENST00000638212
  • ENSP00000492230
  • ENST00000638238
  • ENSP00000492629
  • ENSG00000283750
  • ENST00000638242
  • ENSP00000492364
  • ENST00000638244
  • ENSP00000492699
  • ENSG00000283953
  • ENST00000638285
  • ENSP00000491595
  • ENST00000638290
  • ENSP00000492003
  • ENST00000638453
  • ENSP00000491493
  • ENST00000638527
  • ENSP00000491362
  • ENSG00000284245
  • ENST00000638553
  • ENSP00000491372
  • ENSG00000284004
  • ENST00000638625
  • ENSP00000492755
  • ENST00000638882
  • ENSP00000492226
  • ENST00000638900
  • ENSP00000491778
  • ENST00000638906
  • ENSP00000492268
  • ENST00000638945
  • ENSP00000492228
  • ENST00000638966
  • ENSP00000491307
  • ENST00000638995
  • ENSP00000491741
  • ENST00000639014
  • ENSP00000491039
  • ENST00000639163
  • ENSP00000491556
  • ENST00000639178
  • ENSP00000492137
  • ENST00000639193
  • ENSP00000491447
  • ENST00000639223
  • ENSP00000492274
  • ENST00000639337
  • ENSP00000491914
  • ENST00000639392
  • ENSP00000492068
  • ENST00000639402
  • ENSP00000492442
  • ENST00000639426
  • ENSP00000492415
  • ENST00000639428
  • ENSP00000491642
  • ENST00000639455
  • ENSP00000491849
  • ENST00000639575
  • ENSP00000492321
  • ENST00000639763
  • ENSP00000491420
  • ENST00000640025
  • ENSP00000492529
  • ENST00000640032
  • ENSP00000492077
  • ENST00000640047
  • ENSP00000490997
  • ENST00000640063
  • ENSP00000491889
  • ENST00000640070
  • ENSP00000491192
  • ENST00000640239
  • ENSP00000492762
  • ENST00000640405
  • ENSP00000491490
  • ENST00000640415
  • ENSP00000491274
  • ENST00000640430
  • ENSP00000492494
  • ENST00000640462
  • ENSP00000491298
  • ENST00000640562
  • ENSP00000492074
  • ENST00000640582
  • ENSP00000492447
  • ENST00000640584
  • ENSP00000491818
  • ENST00000640618
  • ENSP00000491815
  • ENST00000640687
  • ENSP00000492597
  • ENST00000640761
  • ENSP00000492411
  • ENST00000640811
  • ENSP00000492678
  • ENST00000640878
  • ENSP00000492686
  • ENST00000640908
  • ENSP00000492162
  • ENST00000640918
  • ENSP00000491746

Symbol
  • CD89
  • CD89
  • FcalphaRI
  • CTB-61M7.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
microRNA
0.6
cell type or tissue
0.58
biological term
0.57
cell line
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.5   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 593   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.5   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 593   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (66)
Items per page:
1 – 5 of 66
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
lymphocyte count
2
1
2
48.5
Items per page:
1 – 5 of 66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
lymphocyte count
2
48.5
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Fc fragment of IgA receptor
664734
Rat
RGD:1303082
365183
Horse
Fc fragment of IgA, receptor for
100050205
Cow
Fc fragment of IgA receptor
VGNC:28929
503555
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Fc fragment of IgA receptor
Rat
Horse
Fc fragment of IgA, receptor for
Cow
Fc fragment of IgA receptor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P24071-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Protein-Protein Interactions (146)
1 – 10 of 146
EFR3B
Tbio
Novelty:  0.61495463
p_int:  0.956064234
p_ni:  0.000042192
p_wrong:  0.043893574
Score:  0.517
Data Source:  BioPlex,STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.966
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.936
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.931
Data Source:  STRINGDB
LAIR1
Tbio
Novelty:  0.0133817
Score:  0.93
Data Source:  STRINGDB
CD93
Tbio
Novelty:  0.01324003
Score:  0.928
Data Source:  STRINGDB
CD33
Tclin
Novelty:  0.00074958
Score:  0.925
Data Source:  STRINGDB
CEACAM8
Tbio
Novelty:  0.00370138
Score:  0.923
Data Source:  STRINGDB
SLC11A1
Tbio
Family:  Transporter
Novelty:  0.00121416
Score:  0.922
Data Source:  STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  257.50

PubMed score by year
PubTator Score  175.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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