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Tchem
GABRR1
Gamma-aminobutyric acid receptor subunit rho-1

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369451
  • ENSP00000358463
  • ENSG00000146276
  • ENST00000435811
  • ENSP00000394687
  • ENST00000454853
  • ENSP00000412673
  • ENST00000611484
  • ENSP00000478846
  • ENST00000621627
  • ENSP00000481986
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.86
cell type or tissue
0.78
drug
0.77
kinase
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.31   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.31   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diabetic nephropathy
1
1
0
1.3
3.3
1
1
0
1.3
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diabetic nephropathy
0
1.3
3.3
0
1.3
3.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor rho1 subunit
VGNC:7889
472068
Macaque
gamma-aminobutyric acid type A receptor rho1 subunit
700728
Mouse
MGI:95625
14408
Rat
RGD:61900
29694
Horse
gamma-aminobutyric acid type A receptor rho1 subunit
VGNC:18204
100070984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor rho1 subunit
Macaque
gamma-aminobutyric acid type A receptor rho1 subunit
Mouse
Rat
Horse
gamma-aminobutyric acid type A receptor rho1 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P24046-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (102)
1 – 10 of 102
GABRR2
Tbio
Family: IC
Novelty: 0.01651914
Score: 0.879
Data Source: Reactome,STRINGDB
GABRR3
Tbio
Family: IC
Novelty: 0.01890426
Score: 0.804
Data Source: Reactome,STRINGDB
GABBR2
Tclin
Family: GPCR
Novelty: 0.00739771
Score: 0.781
Data Source: STRINGDB
GABRA4
Tclin
Family: IC
Novelty: 0.03089903
Score: 0.72
Data Source: STRINGDB
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
Score: 0.719
Data Source: STRINGDB
GABRE
Tclin
Family: IC
Novelty: 0.03814541
Score: 0.715
Data Source: STRINGDB
GABRA1
Tclin
Family: IC
Novelty: 0.0094079
Score: 0.713
Data Source: STRINGDB
GABRG1
Tclin
Family: IC
Novelty: 0.04214561
Score: 0.711
Data Source: STRINGDB
GABRA5
Tclin
Family: IC
Novelty: 0.01499706
Score: 0.711
Data Source: STRINGDB
GABRG3
Tclin
Family: IC
Novelty: 0.0420649
Score: 0.709
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.31

PubMed score by year
PubTator Score  31.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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