Tbio LAMA2 Laminin subunit alpha-2

Protein Summary

Description

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P24043
• Q14736
• Q5VUM2
• Q93022

Gene Name

• LAMA2

Ensembl ID

• ENST00000421865
• ENSP00000400365
• ENSG00000196569

Symbol

• LAMM
• LAMM
• MDC1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
trait	0.97
disease perturbation	0.83
cellular component	0.81
disease	0.72

Protein Classes

PANTHER Classes

Protein / Receptor / Laminin Subunit Alpha-2

Protein / Extracellular Matrix Protein / Extracellular Matrix Linker Protein / Laminin Subunit Alpha-2

Protein / ... / Protease Inhibitor / Laminin Subunit Alpha-2

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Laminin Subunit Alpha-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 530.44   (req: < 5)

Gene RIFs: 64   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 530.44   (req: >= 5)

Gene RIFs: 64   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0