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Tbio
IL32
Interleukin-32

Protein Summary
Description
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000008180
  • ENSP00000008180
  • ENSG00000008517
  • ENST00000325568
  • ENSP00000324742
  • ENST00000382213
  • ENSP00000371648
  • ENST00000396887
  • ENSP00000380096
  • ENST00000396890
  • ENSP00000380099
  • ENST00000440815
  • ENSP00000405063
  • ENST00000444393
  • ENSP00000411958
  • ENST00000525643
  • ENSP00000432218
  • ENST00000526464
  • ENSP00000450364
  • ENST00000528163
  • ENSP00000432850
  • ENST00000529550
  • ENSP00000437020
  • ENST00000530538
  • ENSP00000436929
  • ENST00000530890
  • ENSP00000433747
  • ENST00000531965
  • ENSP00000433177
  • ENST00000533097
  • ENSP00000432917
  • ENST00000534507
  • ENSP00000431775
  • ENST00000548246
  • ENSP00000447979
  • ENST00000548476
  • ENSP00000449483
  • ENST00000548652
  • ENSP00000446624
  • ENST00000549213
  • ENSP00000447812
  • ENST00000551122
  • ENSP00000447496
  • ENST00000552356
  • ENSP00000446978
  • ENST00000552664
  • ENSP00000448683

Symbol
  • NK4
  • TAIF
  • NK4
  • TAIF
  • TAIFa
  • TAIFb
  • TAIFc
  • TAIFd
  • IL-32beta
  • IL-32alpha
  • IL-32delta
  • IL-32gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
small molecule perturbation
0.59
gene perturbation
0.57
PubMedID
0.53
tissue sample
0.51


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.28   (req: < 5)
View Publications
Gene RIFs: 152   (req: <= 3)
View Gene RIFs
Antibodies: 546   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.28   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 32
VGNC:13719
100614360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 32
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P24001-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Reactome
Immune System
2246 targets
R-HSA-168256
Reactome
Other interleukin signaling
287 targets
R-HSA-449836
Reactome
Signaling by Interleukins
619 targets
R-HSA-449147
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Immune System
2246 targets
R-HSA-168256
Other interleukin signaling
287 targets
R-HSA-449836
Signaling by Interleukins
619 targets
R-HSA-449147
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
cytokine activity
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (42)
1 – 10 of 42
PRTN3
Tchem
Family: Enzyme
Novelty: 0.00022728
Score: 0.984
Data Source: Reactome,STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.748
Data Source: STRINGDB
IL18
Tbio
Novelty: 0.00022844
Score: 0.722
Data Source: STRINGDB
IL17A
Tclin
Novelty: 0.00011583
Score: 0.713
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.702
Data Source: STRINGDB
HGF
Tchem
Family: Enzyme
Novelty: 0.00035574
Score: 0.658
Data Source: STRINGDB
IL18RAP
Tbio
Novelty: 0.0141773
Score: 0.653
Data Source: STRINGDB
IDO1
Tchem
Family: Enzyme
Novelty: 0.00131229
Score: 0.644
Data Source: STRINGDB
DNAJA2
Tbio
Novelty: 0.0270624
Score: 0.642
Data Source: STRINGDB
TSLP
Tbio
Novelty: 0.00140333
Score: 0.625
Data Source: STRINGDB
Publication Statistics
PubMed Score  377.28

PubMed score by year
PubTator Score  223.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer