Protein Summary
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- ENST00000008180
- ENSP00000008180
- ENSG00000008517
- ENST00000325568
- ENSP00000324742
- ENST00000382213
- ENSP00000371648
- ENST00000396887
- ENSP00000380096
- ENST00000396890
- ENSP00000380099
- ENST00000440815
- ENSP00000405063
- ENST00000444393
- ENSP00000411958
- ENST00000525643
- ENSP00000432218
- ENST00000526464
- ENSP00000450364
- ENST00000528163
- ENSP00000432850
- ENST00000529550
- ENSP00000437020
- ENST00000530538
- ENSP00000436929
- ENST00000530890
- ENSP00000433747
- ENST00000531965
- ENSP00000433177
- ENST00000533097
- ENSP00000432917
- ENST00000534507
- ENSP00000431775
- ENST00000548246
- ENSP00000447979
- ENST00000548476
- ENSP00000449483
- ENST00000548652
- ENSP00000446624
- ENST00000549213
- ENSP00000447812
- ENST00000551122
- ENSP00000447496
- ENST00000552356
- ENSP00000446978
- ENST00000552664
- ENSP00000448683
- NK4
- TAIF
- NK4
- TAIF
- TAIFa
- TAIFb
- TAIFc
- TAIFd
- IL-32beta
- IL-32alpha
- IL-32delta
- IL-32gamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.83 | ||
small molecule perturbation | 0.59 | ||
gene perturbation | 0.57 | ||
PubMedID | 0.53 | ||
tissue sample | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 431.97 (req: < 5)
Gene RIFs: 152 (req: <= 3)
Antibodies: 546 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 431.97 (req: >= 5)
Gene RIFs: 152 (req: > 3)
Antibodies: 546 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (42)
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Other interleukin signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Other interleukin signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 1 | 1 | 1 | 56.7 | |||||
serum alanine aminotransferase measurement | 1 | 1 | 1 | 22.5 | |||||
brain measurement | 1 | 1 | 0 | 5.8 | 18.4 | ||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 3.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 1 | 56.7 | |||||
serum alanine aminotransferase measurement | 1 | 22.5 | |||||
brain measurement | 0 | 5.8 | 18.4 | ||||
sex hormone-binding globulin measurement | 1 | 3.6 | |||||
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IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 32 | VGNC:13719 | 100614360 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 32 | |||||
Publication Statistics
PubMed Score 431.97
PubMed score by year
PubTator Score 223.61
PubTator score by year
Related Publications
Text Mined References (158)
GeneRif Annotations (152)
Items per page:
0 of 0
PMID | Year | Title |
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