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Tbio
IL32
Interleukin-32

Protein Summary
Description
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000008180
  • ENSP00000008180
  • ENSG00000008517
  • ENST00000325568
  • ENSP00000324742
  • ENST00000382213
  • ENSP00000371648
  • ENST00000396887
  • ENSP00000380096
  • ENST00000396890
  • ENSP00000380099
  • ENST00000440815
  • ENSP00000405063
  • ENST00000444393
  • ENSP00000411958
  • ENST00000525643
  • ENSP00000432218
  • ENST00000526464
  • ENSP00000450364
  • ENST00000528163
  • ENSP00000432850
  • ENST00000529550
  • ENSP00000437020
  • ENST00000530538
  • ENSP00000436929
  • ENST00000530890
  • ENSP00000433747
  • ENST00000531965
  • ENSP00000433177
  • ENST00000533097
  • ENSP00000432917
  • ENST00000534507
  • ENSP00000431775
  • ENST00000548246
  • ENSP00000447979
  • ENST00000548476
  • ENSP00000449483
  • ENST00000548652
  • ENSP00000446624
  • ENST00000549213
  • ENSP00000447812
  • ENST00000551122
  • ENSP00000447496
  • ENST00000552356
  • ENSP00000446978
  • ENST00000552664
  • ENSP00000448683

Symbol
  • NK4
  • TAIF
  • NK4
  • TAIF
  • TAIFa
  • TAIFb
  • TAIFc
  • TAIFd
  • IL-32beta
  • IL-32alpha
  • IL-32delta
  • IL-32gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
small molecule perturbation
0.59
gene perturbation
0.57
PubMedID
0.53
tissue sample
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.95   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 546   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.95   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Other interleukin signaling
Signaling by Interleukins
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (42)
1 – 10 of 42
PRTN3
Tchem
Family: Enzyme
Novelty: 0.00031566
Score: 0.984
Data Source: Reactome,STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.748
Data Source: STRINGDB
IL18
Tbio
Novelty: 0.00038161
Score: 0.722
Data Source: STRINGDB
IL17A
Tclin
Novelty: 0.00018525
Score: 0.713
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.00003644
Score: 0.702
Data Source: STRINGDB
HGF
Tchem
Family: Enzyme
Novelty: 0.00042012
Score: 0.658
Data Source: STRINGDB
IL18RAP
Tbio
Novelty: 0.02250889
Score: 0.653
Data Source: STRINGDB
IDO1
Tchem
Family: Enzyme
Novelty: 0.00188077
Score: 0.644
Data Source: STRINGDB
DNAJA2
Tbio
Novelty: 0.03928803
Score: 0.642
Data Source: STRINGDB
TSLP
Tbio
Novelty: 0.0015318
Score: 0.625
Data Source: STRINGDB
Publication Statistics
PubMed Score  326.95

PubMed score by year
PubTator Score  223.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer