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Tclin
SLC6A2
Sodium-dependent noradrenaline transporter

Protein Summary
Description
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219833
  • ENSP00000219833
  • ENSG00000103546
  • ENST00000379906
  • ENSP00000369237
  • ENST00000567238
  • ENSP00000457375
  • ENST00000568943
  • ENSP00000457473

Symbol
  • NAT1
  • NET1
  • SLC6A5
  • NET
  • NAT1
  • NET1
  • SLC6A5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
co-expressed gene
0.99
ligand (chemical)
0.9
molecular function
0.9
microRNA
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1018.93   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1018.93   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2286
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 65