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Tclin
SLC6A2
Sodium-dependent noradrenaline transporter

Protein Summary
Description
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219833
  • ENSP00000219833
  • ENSG00000103546
  • ENST00000379906
  • ENSP00000369237
  • ENST00000567238
  • ENSP00000457375
  • ENST00000568943
  • ENSP00000457473

Symbol
  • NAT1
  • NET1
  • SLC6A5
  • NET
  • NAT1
  • NET1
  • SLC6A5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
co-expressed gene
0.99
ligand (chemical)
0.9
molecular function
0.9
microRNA
0.73


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 951.06   (req: < 5)
Gene RIFs: 137   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 951.06   (req: >= 5)
Gene RIFs: 137   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2145
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 64
Approved Drugs (64)
1 – 10 of 64
amitriptyline
chemical structure image
chlorpromazine
chemical structure image
metergoline
chemical structure image
cyproheptadine
chemical structure image
ziprasidone
chemical structure image
quetiapine
chemical structure image
clomipramine
chemical structure image
carvedilol
chemical structure image
prochlorperazine
chemical structure image
nortriptyline
chemical structure image
Active Ligands (2145)
1 – 10 of 2145
CHEMBL1909072
chemical structure image
CHEMBL3752900
chemical structure image
CHEMBL180672,CHEMBL2112075
chemical structure image
CHEMBL486278
chemical structure image
CHEMBL3754166
chemical structure image
dosulepin
chemical structure image
CHEMBL221753
chemical structure image
CHEMBL954
chemical structure image
CHEMBL3321791
chemical structure image
CHEMBL3321792
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
31.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 2
VGNC:9017
454096
Macaque
solute carrier family 6 member 2
613238
Mouse
MGI:1270850
20538
Rat
RGD:621822
83511
Dog
solute carrier family 6 member 2
VGNC:46462
487272
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 2
Macaque
solute carrier family 6 member 2
Mouse
Rat
Dog
solute carrier family 6 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P23975-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Defective SLC6A2 causes orthostatic intolerance (OI) (R-HSA-5619109)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC6A2 causes orthostatic intolerance (OI)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Defective SLC6A2 causes orthostatic intolerance (OI)
Disease
Disorders of transmembrane transporters
Na+/Cl- dependent neurotransmitter transporters
SLC transporter disorders
Gene Ontology Terms (22)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (84)
1 – 10 of 84
SLC18A2
Tclin
Family: Transporter
Novelty: 0.00072341
Score: 0.864
Data Source: STRINGDB
SLC5A4
Tchem
Family: Transporter
Novelty: 0.00070175
Score: 0.804
Data Source: STRINGDB
SLC5A2
Tclin
Family: Transporter
Novelty: 0.00066797
Score: 0.804
Data Source: STRINGDB
STX1A
Tbio
Novelty: 0.00087207
Score: 0.775
Data Source: STRINGDB
ADCY7
Tbio
Family: Enzyme
Novelty: 0.00984562
Score: 0.769
Data Source: STRINGDB
RSC1A1
Tbio
Novelty: 0.23664927
Score: 0.766
Data Source: STRINGDB
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.766
Data Source: STRINGDB
SCRT1
Tbio
Family: TF
Novelty: 0.0324512
Score: 0.757
Data Source: STRINGDB
DBH
Tchem
Family: Enzyme
Novelty: 0.00074741
Score: 0.755
Data Source: STRINGDB
YRDC
Tdark
Novelty: 0.01240103
Score: 0.753
Data Source: STRINGDB
Publication Statistics
PubMed Score  951.06

PubMed score by year
PubTator Score  527.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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