Protein Summary
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]
- ENST00000206446
- ENSP00000206446
- ENSG00000092009
- ENST00000250378
- ENSP00000250378
- CYH
- CYM
- CYH
- MCT1
- chymase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.76 | ||
biological term | 0.72 | ||
gene perturbation | 0.67 | ||
co-expressed gene | 0.65 | ||
cellular component | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1399.85 (req: < 5)
Gene RIFs: 81 (req: <= 3)
Antibodies: 369 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1399.85 (req: >= 5)
Gene RIFs: 81 (req: > 3)
Antibodies: 369 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 370
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2