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Tclin
FSHR
Follicle-stimulating hormone receptor

Protein Summary
Description
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690). The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
protein domain
0.92
phenotype
0.71
biological process
0.68
biological term
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.61   (req: < 5)
Gene RIFs: 236   (req: <= 3)
Antibodies: 623   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.61   (req: >= 5)
Gene RIFs: 236   (req: > 3)
Antibodies: 623   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
follicle stimulating hormone measurement
1
1
1
59.8
1
1
0
1.1
55.2
body mass index
1
1
1
46.9
biological sex
1
1
1
46.5
wellbeing measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
follicle stimulating hormone measurement
1
59.8
0
1.1
55.2
body mass index
1
46.9
biological sex
1
46.5
wellbeing measurement
1
15.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
follicle stimulating hormone receptor
VGNC:257
470371
Macaque
follicle stimulating hormone receptor
716123
Mouse
MGI:95583
14309
Rat
RGD:2632
25449
Dog
follicle stimulating hormone receptor
VGNC:40997
481367
Species
Name
OMA
EggNOG
Inparanoid
Chimp
follicle stimulating hormone receptor
Macaque
follicle stimulating hormone receptor
Mouse
Rat
Dog
follicle stimulating hormone receptor
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23945-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hormone ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Hormone ligand-binding receptors
Protein-Protein Interactions (225)
1 – 10 of 225
DNAJC18
Tdark
Novelty:  1.38573997
p_int:  0.994119605
p_ni:  0.005880395
Data Source:  BioPlex
DAD1
Tbio
Family:  Enzyme
Novelty:  0.00653242
p_int:  0.992653135
p_ni:  0.007346789
p_wrong:  7.7e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
EDA
Tbio
Novelty:  0.00352464
p_int:  0.974557192
p_ni:  0.004808251
p_wrong:  0.020634557
Data Source:  BioPlex
ABCD4
Tbio
Family:  Transporter
Novelty:  0.04096359
p_int:  0.973895592
p_ni:  0.026083556
p_wrong:  0.000020852
Score:  0.552
Data Source:  BioPlex,STRINGDB
UPK3BL1
Tdark
Novelty:  5
p_int:  0.96448794
p_ni:  0.03551206
Data Source:  BioPlex
C2CD2L
Tbio
Novelty:  0.2051681
p_int:  0.963259887
p_ni:  0.036485739
p_wrong:  0.000254374
Data Source:  BioPlex
NAGPA
Tbio
Family:  Enzyme
Novelty:  0.03136768
p_int:  0.961821461
p_ni:  0.037729931
p_wrong:  0.000448608
Score:  0.179
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.936196496
p_ni:  0.063803504
Data Source:  BioPlex
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.933946013
p_ni:  0.06602813
p_wrong:  0.000025857
Score:  0.275
Data Source:  BioPlex,STRINGDB
ABHD6
Tchem
Family:  Enzyme
Novelty:  0.019314
p_int:  0.925110704
p_ni:  0.000662992
p_wrong:  0.074226304
Score:  0.207
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  864.61

PubMed score by year
PubTator Score  681.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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