FSHR
Follicle-stimulating hormone receptor
Protein Summary
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690). The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
- ENST00000304421
- ENSP00000306780
- ENSG00000170820
- LGR1
- LGR1
- ODG1
- FSHR1
- FSHRO
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.99 | ||
protein domain | 0.92 | ||
phenotype | 0.71 | ||
biological process | 0.68 | ||
biological term | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 939.57 (req: < 5)
Gene RIFs: 286 (req: <= 3)
Antibodies: 623 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 939.57 (req: >= 5)
Gene RIFs: 286 (req: > 3)
Antibodies: 623 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 32
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2