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Tclin
RRM1
Ribonucleoside-diphosphate reductase large subunit

Protein Summary
Description
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300738
  • ENSP00000300738
  • ENSG00000167325

Symbol
  • RR1
  • R1
  • RR1
  • RIR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
0.97
transcription factor binding site profile
0.92
kinase perturbation
0.91
transcription factor perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1189.03   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 555   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1189.03   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 555   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (1)
1 – 1 of 1
fludarabine
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
86
mean corpuscular hemoglobin concentration
1
1
1
82.5
mean corpuscular volume
1
2
2
58.3
mean reticulocyte volume
1
1
1
48.8
mean corpuscular hemoglobin
1
1
1
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
86
mean corpuscular hemoglobin concentration
1
82.5
mean corpuscular volume
2
58.3
mean reticulocyte volume
1
48.8
mean corpuscular hemoglobin
1
13.1
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonucleotide reductase catalytic subunit M1
VGNC:1011
450974
Macaque
ribonucleotide reductase catalytic subunit M1
717990
Mouse
MGI:98180
20133
Rat
RGD:1592569
685579
Dog
ribonucleotide reductase catalytic subunit M1
VGNC:45760
476823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonucleotide reductase catalytic subunit M1
Macaque
ribonucleotide reductase catalytic subunit M1
Mouse
Rat
Dog
ribonucleotide reductase catalytic subunit M1
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (383)
1 – 10 of 383
RRM2B
Tbio
Family: Enzyme
Novelty: 0.00817283
p_int: 0.999999871
p_ni: 1.28e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GLRX3
Tbio
Novelty: 0.0096265
p_int: 0.999990513
p_ni: 0.000009487
Score: 0.311
Data Source: BioPlex,STRINGDB
RRM2
Tclin
Family: Enzyme
Novelty: 0.00112948
p_int: 0.998967162
p_ni: 0.001032838
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TMEM184A
Tbio
Novelty: 0.16408207
p_int: 0.997308115
p_ni: 0.002691885
Score: 0.193
Data Source: BioPlex,STRINGDB
ARL5B
Tbio
Family: Enzyme
Novelty: 0.03703395
p_int: 0.918586138
p_ni: 0.081413862
Score: 0.193
Data Source: BioPlex,STRINGDB
KAT5
Tchem
Family: Epigenetic
Novelty: 0.00368348
p_int: 0.907229292
p_ni: 0.092770708
Score: 0.443
Data Source: BioPlex,STRINGDB
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.8585147
p_ni: 0.1414853
Data Source: BioPlex
TRIM69
Tbio
Family: Enzyme
Novelty: 0.18807436
p_int: 0.780180011
p_ni: 0.219819989
Score: 0.226
Data Source: BioPlex,STRINGDB
MCM4
Tbio
Novelty: 0.00604311
Score: 0.984
Data Source: STRINGDB
TYMS
Tclin
Family: Enzyme
Novelty: 0.00087522
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  1189.03

PubMed score by year
PubTator Score  1873.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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