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Tbio
GATA3
Trans-acting T-cell-specific transcription factor GATA-3

Protein Summary
Description
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346208
  • ENSP00000341619
  • ENSG00000107485
  • ENST00000379328
  • ENSP00000368632
  • ENST00000645492
  • ENSP00000494926

Symbol
  • HDR
  • HDRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
PubMedID
1
transcription factor binding site profile
0.85
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1468.17   (req: < 5)
Gene RIFs: 306   (req: <= 3)
Antibodies: 846   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1468.17   (req: >= 5)
Gene RIFs: 306   (req: > 3)
Antibodies: 846   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 119
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (451)
1 – 10 of 451
TBX21
Tbio
Family:  TF
Novelty:  0.0009971
Score:  0.996
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.99
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.99
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.988
Data Source:  Reactome,STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.988
Data Source:  Reactome,STRINGDB
IL5
Tclin
Novelty:  0.0001684
Score:  0.988
Data Source:  STRINGDB
LMO2
Tbio
Novelty:  0.0038279
Score:  0.986
Data Source:  STRINGDB
TAL1
Tbio
Family:  TF
Novelty:  0.00294416
Score:  0.985
Data Source:  STRINGDB
MYB
Tbio
Family:  TF
Novelty:  0.00092053
Score:  0.981
Data Source:  STRINGDB
IL33
Tbio
Novelty:  0.00072064
Score:  0.978
Data Source:  STRINGDB
Pathways (40)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Deubiquitination
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Factors involved in megakaryocyte development and platelet production
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Deubiquitination
ESR-mediated signaling
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production
Gene Ontology Terms (122)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
88
eosinophil count
3
2
3
83
eosinophil percentage of leukocytes
1
1
1
73.9
calcium measurement
1
2
2
70.9
lymphocyte percentage of leukocytes
1
1
1
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
88
eosinophil count
3
83
eosinophil percentage of leukocytes
1
73.9
calcium measurement
2
70.9
lymphocyte percentage of leukocytes
1
67.7
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GATA binding protein 3
VGNC:3862
450296
Macaque
GATA binding protein 3
713840
Mouse
MGI:95663
14462
Rat
RGD:621250
85471
Dog
GATA binding protein 3
VGNC:41123
487134
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GATA binding protein 3
Macaque
GATA binding protein 3
Mouse
Rat
Dog
GATA binding protein 3
Publication Statistics
PubMed Score 1468.17
PubMed score by year
PubTator Score 772.49
PubTator score by year