GATA3
Trans-acting T-cell-specific transcription factor GATA-3
Protein Summary
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
- ENST00000346208
- ENSP00000341619
- ENSG00000107485
- ENST00000379328
- ENSP00000368632
- ENST00000645492
- ENSP00000494926
- HDR
- HDRS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
PubMedID | 1 | ||
transcription factor binding site profile | 0.85 | ||
kinase perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1722.06 (req: < 5)
Gene RIFs: 423 (req: <= 3)
Antibodies: 846 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1722.06 (req: >= 5)
Gene RIFs: 423 (req: > 3)
Antibodies: 846 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 119
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0