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Tbio
VAMP1
Vesicle-associated membrane protein 1

Protein Summary
Description
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361716
  • ENSP00000355122
  • ENSG00000139190
  • ENST00000396308
  • ENSP00000379602
  • ENST00000400911
  • ENSP00000383702

Symbol
  • SYB1
  • SYB1
  • CMS25
  • SPAX1
  • VAMP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.92
histone modification site profile
0.81
transcription factor binding site profile
0.77
microRNA
0.73
small molecule perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.63   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.63   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
4
96
platelet crit
2
4
4
93.3
monocyte count
2
2
2
88.7
monocyte percentage of leukocytes
2
1
2
87.6
neutrophil percentage of leukocytes
2
2
2
85.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
96
platelet crit
4
93.3
monocyte count
2
88.7
monocyte percentage of leukocytes
2
87.6
neutrophil percentage of leukocytes
2
85.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1313276
22317
Rat
RGD:3948
25624
Dog
vesicle associated membrane protein 1
VGNC:54386
486726
Horse
vesicle associated membrane protein 1
VGNC:24875
100059722
Cow
vesicle associated membrane protein 1
VGNC:36756
513621
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
vesicle associated membrane protein 1
Horse
vesicle associated membrane protein 1
Cow
vesicle associated membrane protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P23763-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (29)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Neurotoxicity of clostridium toxins
Reactome
Toxicity of botulinum toxin type D (BoNT/D)
Reactome
Toxicity of botulinum toxin type F (BoNT/F)
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Neurotoxicity of clostridium toxins
Toxicity of botulinum toxin type D (BoNT/D)
Toxicity of botulinum toxin type F (BoNT/F)
Gene Ontology Terms (15)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (119)
1 – 10 of 119
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.986
Data Source:  STRINGDB
VAPA
Tbio
Novelty:  0.00169209
Score:  0.97
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.966
Data Source:  STRINGDB
STX1B
Tbio
Novelty:  0.01171833
Score:  0.948
Data Source:  STRINGDB
VAMP3
Tbio
Novelty:  0.00694332
Score:  0.945
Data Source:  STRINGDB
SNAP23
Tbio
Novelty:  0.0065371
Score:  0.943
Data Source:  STRINGDB
STX4
Tbio
Novelty:  0.00831588
Score:  0.938
Data Source:  STRINGDB
VTI1B
Tbio
Novelty:  0.00955467
Score:  0.903
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.882
Data Source:  STRINGDB
STX3
Tbio
Novelty:  0.01055819
Score:  0.877
Data Source:  STRINGDB
Publication Statistics
PubMed Score  83.63

PubMed score by year
PubTator Score  39.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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