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Tbio
PAX7
Paired box protein Pax-7

Protein Summary
Description
Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation. This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375375
  • ENSP00000364524
  • ENSG00000009709
  • ENST00000400661
  • ENSP00000383502
  • ENST00000420770
  • ENSP00000403389

Symbol
  • HUP1
  • HUP1
  • RMS2
  • PAX7B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
biological process
0.89
protein domain
0.85
gene perturbation
0.83
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 952.51   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 645   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 952.51   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 645   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0