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Tbio
PAX7
Paired box protein Pax-7

Protein Summary
Description
Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation. This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375375
  • ENSP00000364524
  • ENSG00000009709
  • ENST00000400661
  • ENSP00000383502
  • ENST00000420770
  • ENSP00000403389

Symbol
  • HUP1
  • HUP1
  • RMS2
  • PAX7B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
biological process
0.89
protein domain
0.85
gene perturbation
0.83
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 756.82   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 645   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 756.82   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 645   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1.5
93.3
cortical surface area measurement
1
1
0
12.2
84.2
Cleft palate
1
2
0
1.5
72.1
Oral cleft
1
1
0
1.3
47.2
visual cortical surface area measurement
1
1
1
20.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.5
93.3
cortical surface area measurement
0
12.2
84.2
Cleft palate
0
1.5
72.1
Oral cleft
0
1.3
47.2
visual cortical surface area measurement
1
20.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paired box 7
VGNC:1439
456574
Macaque
paired box 7
702013
Mouse
MGI:97491
18509
Rat
RGD:1564360
500574
Dog
paired box 7
VGNC:52224
487408
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paired box 7
Macaque
paired box 7
Mouse
Rat
Dog
paired box 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P23759-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (142)
1 – 10 of 142
MYOD1
Tbio
Family: TF
Novelty: 0.00053412
Score: 0.966
Data Source: STRINGDB
MYF5
Tbio
Family: TF
Novelty: 0.00229001
Score: 0.952
Data Source: STRINGDB
MYOG
Tbio
Family: TF
Novelty: 0.00074867
Score: 0.945
Data Source: STRINGDB
MSTN
Tclin
Novelty: 0.00062316
Score: 0.84
Data Source: STRINGDB
MYF6
Tbio
Family: TF
Novelty: 0.00509046
Score: 0.82
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.79
Data Source: STRINGDB
EYA1
Tbio
Novelty: 0.00585286
Score: 0.758
Data Source: STRINGDB
SDC4
Tbio
Novelty: 0.00319073
Score: 0.748
Data Source: STRINGDB
FOXD3
Tbio
Family: TF
Novelty: 0.00550321
Score: 0.744
Data Source: STRINGDB
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
Score: 0.726
Data Source: STRINGDB
Publication Statistics
PubMed Score  756.82

PubMed score by year
PubTator Score  273.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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