DGKA
Diacylglycerol kinase alpha
Protein Summary
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
- ENST00000331886
- ENSP00000328405
- ENSG00000065357
- ENST00000394147
- ENSP00000377703
- ENST00000402956
- ENSP00000385792
- ENST00000548549
- ENSP00000448565
- ENST00000551156
- ENSP00000450359
- ENST00000553084
- ENSP00000446605
- DAGK
- DAGK1
- DAGK
- DAGK1
- DGK-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.96 | ||
metabolite | 0.85 | ||
kinase perturbation | 0.84 | ||
transcription factor | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 173.22 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 389 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 173.22 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 389 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0