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Tbio
DGKA
Diacylglycerol kinase alpha

Protein Summary
Description
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331886
  • ENSP00000328405
  • ENSG00000065357
  • ENST00000394147
  • ENSP00000377703
  • ENST00000402956
  • ENSP00000385792
  • ENST00000548549
  • ENSP00000448565
  • ENST00000551156
  • ENSP00000450359
  • ENST00000553084
  • ENSP00000446605

Symbol
  • DAGK
  • DAGK1
  • DAGK
  • DAGK1
  • DGK-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.96
metabolite
0.85
kinase perturbation
0.84
transcription factor
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.95   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.95   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
3
3
3.4
93.8
4
3
0
1.3
93.1
6
5
0
1.1
91.7
3
3
0
1.3
91.5
childhood onset asthma
2
2
0
1.1
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3.4
93.8
0
1.3
93.1
0
1.1
91.7
0
1.3
91.5
childhood onset asthma
0
1.1
87.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase alpha
VGNC:5356
451976
Macaque
diacylglycerol kinase alpha
710559
Mouse
MGI:102952
13139
Rat
RGD:70904
140866
Dog
diacylglycerol kinase alpha
VGNC:39915
100855691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase alpha
Macaque
diacylglycerol kinase alpha
Mouse
Rat
Dog
diacylglycerol kinase alpha
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23743-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (77)
1 – 10 of 77
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.902978798
p_ni:  0.097013613
p_wrong:  0.000007589
Score:  0.156
Data Source:  BioPlex,STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.783
Data Source:  STRINGDB
MOGAT1
Tbio
Family:  Enzyme
Novelty:  0.0503068
Score:  0.768
Data Source:  STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
Score:  0.767
Data Source:  STRINGDB
CDS2
Tbio
Family:  Enzyme
Novelty:  0.13210626
Score:  0.75
Data Source:  STRINGDB
PLCE1
Tbio
Family:  Enzyme
Novelty:  0.0070258
Score:  0.744
Data Source:  STRINGDB
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
Score:  0.741
Data Source:  STRINGDB
AGPAT2
Tchem
Family:  Enzyme
Novelty:  0.01321334
Score:  0.738
Data Source:  STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
Score:  0.733
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.728
Data Source:  STRINGDB
Publication Statistics
PubMed Score  156.95

PubMed score by year
PubTator Score  65.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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