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Tchem
ITPKA
Inositol-trisphosphate 3-kinase A

Protein Classes
Protein Summary
Description
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260386
  • ENSP00000260386
  • ENSG00000137825

Symbol
  • IP3KA
  • IP3-3KA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
cell type or tissue
0.83
gene perturbation
0.77
transcription factor binding site profile
0.72
histone modification site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.5   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.5   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
GNF362
chemical structure image
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (68)
1 – 10 of 68
IPMK
Tbio
Family: Kinase
Novelty: 0.02115444
Score: 0.964
Data Source: STRINGDB
INPP5A
Tchem
Family: Enzyme
Novelty: 0.03832271
Score: 0.962
Data Source: STRINGDB
ITPK1
Tbio
Family: Kinase
Novelty: 0.03799195
Score: 0.942
Data Source: STRINGDB
PLCB2
Tbio
Family: Enzyme
Novelty: 0.00689922
Score: 0.942
Data Source: STRINGDB
MINPP1
Tbio
Family: Enzyme
Novelty: 0.03074783
Score: 0.94
Data Source: STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00370802
Score: 0.926
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00125418
Score: 0.926
Data Source: STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00821462
Score: 0.925
Data Source: STRINGDB
INPP5J
Tbio
Family: Enzyme
Novelty: 0.01304557
Score: 0.921
Data Source: STRINGDB
PLCE1
Tbio
Family: Enzyme
Novelty: 0.00779856
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.50

PubMed score by year
PubTator Score  22.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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