Tbio ATP2B4 Plasma membrane calcium-transporting ATPase 4

Protein Summary

Description

Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P23634
• B1APW5
• B1APW6
• Q13450
• Q13452
• Q13455
• Q16817
• Q7Z3S1
• PMCA4

Gene Name

• ATP2B4

Ensembl ID

• ENST00000341360
• ENSP00000340930
• ENSG00000058668
• ENST00000357681
• ENSP00000350310
• ENST00000367218
• ENSP00000356187

Symbol

• ATP2B2
• MXRA1
• MXRA1
• PMCA4
• ATP2B2
• PMCA4b
• PMCA4x

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
protein domain	1
virus perturbation	1
kinase perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Plasma Membrane Calcium-transporting Atpase 4

Protein / Transporter / Cation Transporter / Plasma Membrane Calcium-transporting Atpase 4

Protein / Hydrolase / Plasma Membrane Calcium-transporting Atpase 4

DTO Classes

Protein / Transporter / P-type Atpases / Ca2+-atpases / Plasma Membrane Calcium-transporting Atpase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.07   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.07   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0