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Tbio
ATP2B4
Plasma membrane calcium-transporting ATPase 4

Protein Summary
Description
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adap ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341360
  • ENSP00000340930
  • ENSG00000058668
  • ENST00000357681
  • ENSP00000350310
  • ENST00000367218
  • ENSP00000356187

Symbol
  • ATP2B2
  • MXRA1
  • MXRA1
  • PMCA4
  • ATP2B2
  • PMCA4b
  • PMCA4x
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
virus perturbation
1
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.11   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.11   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
HSD17B6
Tbio
Family:  Enzyme
Novelty:  0.01428594
p_int:  0.999991122
p_ni:  0.000008878
Score:  0.161
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999989341
p_ni:  0.000010659
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999981125
p_ni:  0.000018875
Score:  0.183
Data Source:  BioPlex,STRINGDB
LHFPL2
Tdark
Novelty:  0.85421144
p_int:  0.999961361
p_ni:  0.000038639
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.999948669
p_ni:  0.000051329
p_wrong:  2e-9
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.99986842
p_ni:  0.00013158
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.999862002
p_ni:  0.000137998
Score:  0.159
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999778435
p_ni:  0.000221565
Data Source:  BioPlex
LGALS9C
Tdark
Novelty:  0.29969898
p_int:  0.999611353
p_ni:  0.000388647
Score:  0.527
Data Source:  BioPlex,STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.999522301
p_ni:  0.000477699
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
98.2
hemoglobin measurement
3
3
3
94.5
hip circumference
1
7
7
94.1
lymphocyte count
3
3
3
92.8
BMI-adjusted hip circumference
1
7
7
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
98.2
hemoglobin measurement
3
94.5
hip circumference
7
94.1
lymphocyte count
3
92.8
BMI-adjusted hip circumference
7
92.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase plasma membrane Ca2+ transporting 4
VGNC:8032
457646
Mouse
MGI:88111
381290
Rat
RGD:621305
29600
Dog
ATPase plasma membrane Ca2+ transporting 4
VGNC:38259
403731
Horse
ATPase plasma membrane Ca2+ transporting 4
VGNC:49512
100049920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase plasma membrane Ca2+ transporting 4
Mouse
Rat
Dog
ATPase plasma membrane Ca2+ transporting 4
Horse
ATPase plasma membrane Ca2+ transporting 4
Publication Statistics
PubMed Score 189.11
PubMed score by year
PubTator Score 96.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title