Tbio EIF4B Eukaryotic translation initiation factor 4B

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4B

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4B

Protein Summary

Description

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Uniprot Accession IDs

• P23588
• B4DS13
• Q4G0E3
• Q53HQ2
• Q6GPH5
• Q6IB46
• Q8WYK5
• eIF-4B

Gene Name

• EIF4B

Ensembl ID

• ENST00000262056
• ENSP00000262056
• ENSG00000063046
• ENST00000416762
• ENSP00000412530

Symbol

• EIF-4B
• PRO1843

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
transcription factor perturbation	1
disease perturbation	0.99
kinase perturbation	0.99
interacting protein	0.98

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.82   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 757   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.82   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 757   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (25)

Reactome (15)

KEGG (4)

PathwayCommons (1)

WikiPathways (5)

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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Items per page:

5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Deadenylation of mRNA	22 targets	R-HSA-429947
Reactome	Deadenylation-dependent mRNA decay	53 targets	R-HSA-429914
Reactome	Eukaryotic Translation Initiation	121 targets	R-HSA-72613

Name	Explore in Pharos	Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Deadenylation of mRNA	22 targets	R-HSA-429947
Deadenylation-dependent mRNA decay	53 targets	R-HSA-429914
Eukaryotic Translation Initiation	121 targets	R-HSA-72613

Gene Ontology Terms (13)

Functions (5)

Components (3)

Processes (5)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ribosomal small subunit binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA strand annealing activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA strand-exchange activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
translation initiation factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (353)

Explore Interacting Targets

1 – 10 of 353

• See Interactions on String-DB

RBM12B

Tdark

Novelty: 7.74193548

p_int: 1

Data Source: BioPlex

NIF3L1

Tbio

Novelty: 0.21052632

p_int: 0.999443417

p_ni: 0.000556583

Data Source: BioPlex

NCOA5

Tbio

Novelty: 0.07301749

p_int: 0.982891694

p_ni: 0.017078213

p_wrong: 0.000030093

Score: 0.181

Data Source: BioPlex,STRINGDB

EIF4G1

Tbio

Novelty: 0.00219215

Score: 0.999

Data Source: Reactome,STRINGDB

EIF4A1

Tchem

Novelty: 0.0043238

Score: 0.999

Data Source: Reactome,STRINGDB

RPS6

Tbio

Novelty: 0.00155552

Score: 0.998

Data Source: STRINGDB

EIF4A2

Tbio

Novelty: 0.00471357

Score: 0.998

Data Source: Reactome,STRINGDB

EIF4E

Tchem

Novelty: 0.00088513

Score: 0.996

Data Source: Reactome,STRINGDB

EIF3A

Tbio

Novelty: 0.00483199

Score: 0.996

Data Source: STRINGDB

PABPC1

Tbio

Novelty: 0.002455

Score: 0.995

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  104.82

PubMed score by year

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PubTator Score  107.07

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDR

1-70

SILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFG

70-140

YAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDD

140-210

YPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRA

210-280

FGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSAS

280-350

TSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRT

350-420

GSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSN

420-490

PPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESD

490-560

RKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

560-611

MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Initiation factor
Isopeptide bond
Phosphoprotein
Polymorphism
Protein biosynthesis