EIF4B
Eukaryotic translation initiation factor 4B
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 1 | ||
transcription factor perturbation | 1 | ||
disease perturbation | 0.99 | ||
kinase perturbation | 0.99 | ||
interacting protein | 0.98 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Deadenylation of mRNA | ||||
Reactome | Deadenylation-dependent mRNA decay | ||||
Reactome | Eukaryotic Translation Initiation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Cap-dependent Translation Initiation | ||||
Deadenylation of mRNA | ||||
Deadenylation-dependent mRNA decay | ||||
Eukaryotic Translation Initiation | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
3 | 2 | 0 | 1.2 | 85 | |||||
mathematical ability | 1 | 2 | 2 | 40.5 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 33.1 | |||||
body height | 1 | 1 | 1 | 27.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 21.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 85 | |||||
mathematical ability | 2 | 40.5 | |||||
mean reticulocyte volume | 1 | 33.1 | |||||
body height | 1 | 27.2 | |||||
self reported educational attainment | 1 | 21.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:95304 | 75705 | ||||||
Rat | RGD:1306479 | 300253 | ||||||
Dog | eukaryotic translation initiation factor 4B | VGNC:40282 | 477600 | |||||
Horse | eukaryotic translation initiation factor 4B | VGNC:17501 | 100061920 | |||||
Cow | eukaryotic translation initiation factor 4B | VGNC:28407 | 505850 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | eukaryotic translation initiation factor 4B | |||||
Horse | eukaryotic translation initiation factor 4B | |||||
Cow | eukaryotic translation initiation factor 4B | |||||
PMID | Year | Title |
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