EIF4B
Eukaryotic translation initiation factor 4B
Protein Summary
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
- ENST00000262056
- ENSP00000262056
- ENSG00000063046
- ENST00000416762
- ENSP00000412530
- EIF-4B
- PRO1843
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
transcription factor perturbation | 1 | ||
disease perturbation | 0.99 | ||
kinase perturbation | 0.99 | ||
interacting protein | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.09 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 757 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.09 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 757 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (353)
NCOA5
Novelty: 0.09053523
p_int: 0.982891694
p_ni: 0.017078213
p_wrong: 0.000030093
Score: 0.181
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (25)
Reactome (15)
KEGG (4)
PathwayCommons (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Deadenylation of mRNA | ||||
Reactome | Deadenylation-dependent mRNA decay | ||||
Reactome | Eukaryotic Translation Initiation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Cap-dependent Translation Initiation | ||||
Deadenylation of mRNA | ||||
Deadenylation-dependent mRNA decay | ||||
Eukaryotic Translation Initiation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (5)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 0 | 1.2 | 93.4 | |||||
low density lipoprotein cholesterol measurement | 3 | 2 | 3 | 66.8 | |||||
systolic blood pressure | 2 | 2 | 2 | 60.9 | |||||
educational attainment | 1 | 3 | 3 | 58.9 | |||||
appendicular lean mass | 1 | 1 | 1 | 57.1 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 93.4 | |||||
low density lipoprotein cholesterol measurement | 3 | 66.8 | |||||
systolic blood pressure | 2 | 60.9 | |||||
educational attainment | 3 | 58.9 | |||||
appendicular lean mass | 1 | 57.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:95304 | 75705 | ||||||
Rat | RGD:1306479 | 300253 | ||||||
Dog | eukaryotic translation initiation factor 4B | VGNC:40282 | 477600 | |||||
Horse | eukaryotic translation initiation factor 4B | VGNC:17501 | 100061920 | |||||
Cow | eukaryotic translation initiation factor 4B | VGNC:28407 | 505850 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | eukaryotic translation initiation factor 4B | |||||
Horse | eukaryotic translation initiation factor 4B | |||||
Cow | eukaryotic translation initiation factor 4B | |||||
Publication Statistics
PubMed Score 141.09
PubMed score by year
PubTator Score 107.07
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (24)
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0 of 0
PMID | Year | Title |
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