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Tbio
EIF4B
Eukaryotic translation initiation factor 4B

Protein Summary
Description
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262056
  • ENSP00000262056
  • ENSG00000063046
  • ENST00000416762
  • ENSP00000412530

Symbol
  • EIF-4B
  • PRO1843
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor perturbation
1
disease perturbation
0.99
kinase perturbation
0.99
interacting protein
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.57   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 757   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.57   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 757   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
52
electrocardiography
1
1
1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
52
electrocardiography
1
9.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95304
75705
Rat
RGD:1306479
300253
Dog
eukaryotic translation initiation factor 4B
VGNC:40282
477600
Horse
eukaryotic translation initiation factor 4B
VGNC:17501
100061920
Cow
eukaryotic translation initiation factor 4B
VGNC:28407
505850
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
eukaryotic translation initiation factor 4B
Horse
eukaryotic translation initiation factor 4B
Cow
eukaryotic translation initiation factor 4B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23588-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Eukaryotic Translation Initiation
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Eukaryotic Translation Initiation
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (353)
1 – 10 of 353
RBM12B
Tdark
Novelty: 0.96079205
p_int: 1
Data Source: BioPlex
NIF3L1
Tbio
Novelty: 0.15581813
p_int: 0.999443417
p_ni: 0.000556583
Data Source: BioPlex
NCOA5
Tbio
Novelty: 0.09053523
p_int: 0.982891694
p_ni: 0.017078213
p_wrong: 0.000030093
Score: 0.181
Data Source: BioPlex,STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
Score: 0.999
Data Source: Reactome,STRINGDB
EIF4A1
Tchem
Novelty: 0.00269994
Score: 0.999
Data Source: Reactome,STRINGDB
RPS6
Tbio
Novelty: 0.00122241
Score: 0.998
Data Source: STRINGDB
EIF4A2
Tbio
Novelty: 0.00298045
Score: 0.998
Data Source: Reactome,STRINGDB
EIF4E
Tchem
Novelty: 0.00072182
Score: 0.996
Data Source: Reactome,STRINGDB
EIF3A
Tbio
Novelty: 0.00434615
Score: 0.996
Data Source: STRINGDB
PABPC1
Tbio
Novelty: 0.00197523
Score: 0.995
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  126.57

PubMed score by year
PubTator Score  107.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer