Tbio EIF4B Eukaryotic translation initiation factor 4B

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4B

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4B

Protein Summary

Description

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Uniprot Accession IDs

• P23588
• B4DS13
• Q4G0E3
• Q53HQ2
• Q6GPH5
• Q6IB46
• Q8WYK5
• eIF-4B

Gene Name

• EIF4B

Ensembl ID

• ENST00000262056
• ENSP00000262056
• ENSG00000063046
• ENST00000416762
• ENSP00000412530

Symbol

• EIF-4B
• PRO1843

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
transcription factor perturbation	1
disease perturbation	0.99
kinase perturbation	0.99
interacting protein	0.98

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.57   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 757   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.57   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 757   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1	1	1		52
electrocardiography	EFO_0004327	1	1	1		9.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	1		52
electrocardiography	EFO_0004327	1		9.8

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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	eukaryotic translation initiation factor 4B	MGI:95304	75705
Rat	eukaryotic translation initiation factor 4B	RGD:1306479	300253
Dog	eukaryotic translation initiation factor 4B	VGNC:40282	477600
Horse	eukaryotic translation initiation factor 4B	VGNC:17501	100061920
Cow	eukaryotic translation initiation factor 4B	VGNC:28407	505850

Species	Name	OMA	EggNOG	Inparanoid
Mouse	eukaryotic translation initiation factor 4B
Rat	eukaryotic translation initiation factor 4B
Dog	eukaryotic translation initiation factor 4B
Horse	eukaryotic translation initiation factor 4B
Cow	eukaryotic translation initiation factor 4B

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23588-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (25)

Reactome (15)

KEGG (4)

PathwayCommons (1)

WikiPathways (5)

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Deadenylation of mRNA	22 targets	R-HSA-429947
Reactome	Deadenylation-dependent mRNA decay	53 targets	R-HSA-429914
Reactome	Eukaryotic Translation Initiation	121 targets	R-HSA-72613

Name	Explore in Pharos	Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Deadenylation of mRNA	22 targets	R-HSA-429947
Deadenylation-dependent mRNA decay	53 targets	R-HSA-429914
Eukaryotic Translation Initiation	121 targets	R-HSA-72613

Gene Ontology Terms (13)

Functions (5)

Components (3)

Processes (5)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ribosomal small subunit binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA strand annealing activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA strand-exchange activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
translation initiation factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (353)

Explore Interacting Targets

1 – 10 of 353

• See Interactions on String-DB

RBM12B

Tdark

Novelty: 0.96079205

p_int: 1

Data Source: BioPlex

NIF3L1

Tbio

Novelty: 0.15581813

p_int: 0.999443417

p_ni: 0.000556583

Data Source: BioPlex

NCOA5

Tbio

Novelty: 0.09053523

p_int: 0.982891694

p_ni: 0.017078213

p_wrong: 0.000030093

Score: 0.181

Data Source: BioPlex,STRINGDB

EIF4G1

Tbio

Novelty: 0.00170995

Score: 0.999

Data Source: Reactome,STRINGDB

EIF4A1

Tchem

Novelty: 0.00269994

Score: 0.999

Data Source: Reactome,STRINGDB

RPS6

Tbio

Novelty: 0.00122241

Score: 0.998

Data Source: STRINGDB

EIF4A2

Tbio

Novelty: 0.00298045

Score: 0.998

Data Source: Reactome,STRINGDB

EIF4E

Tchem

Novelty: 0.00072182

Score: 0.996

Data Source: Reactome,STRINGDB

EIF3A

Tbio

Novelty: 0.00434615

Score: 0.996

Data Source: STRINGDB

PABPC1

Tbio

Novelty: 0.00197523

Score: 0.995

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  126.57

PubMed score by year

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PubTator Score  107.07

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Initiation factor
Isopeptide bond
Phosphoprotein
Polymorphism
Protein biosynthesis

GWAS Trait Find Similar Targets

electrocardiography
mathematical ability