Tbio EIF4B Eukaryotic translation initiation factor 4B

Protein Summary

Description

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Uniprot Accession IDs

• P23588
• B4DS13
• Q4G0E3
• Q53HQ2
• Q6GPH5
• Q6IB46
• Q8WYK5
• eIF-4B

Gene Name

• EIF4B

Ensembl ID

• ENST00000262056
• ENSP00000262056
• ENSG00000063046
• ENST00000416762
• ENSP00000412530

Symbol

• EIF-4B
• PRO1843

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
transcription factor perturbation	1
disease perturbation	0.99
kinase perturbation	0.99
interacting protein	0.98

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4b

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.09   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 757   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.09   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 757   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0