BDNF
Brain-derived neurotrophic factor
Protein Summary
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene i ...more
- ENST00000314915
- ENSP00000320002
- ENSG00000176697
- ENST00000356660
- ENSP00000349084
- ENST00000395978
- ENSP00000379302
- ENST00000395980
- ENSP00000379304
- ENST00000395981
- ENSP00000379305
- ENST00000395983
- ENSP00000379307
- ENST00000395986
- ENSP00000379309
- ENST00000418212
- ENSP00000400502
- ENST00000420794
- ENSP00000389564
- ENST00000438929
- ENSP00000414303
- ENST00000439476
- ENSP00000389345
- ENST00000525528
- ENSP00000437138
- ENST00000525950
- ENSP00000432035
- ENST00000530861
- ENSP00000435564
- ENST00000532997
- ENSP00000435805
- ENST00000533131
- ENSP00000432727
- ENST00000533246
- ENSP00000432376
- ANON2
- BULN2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
PubMedID | 0.98 | ||
cellular component | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19737.65 (req: < 5)
Gene RIFs: 2281 (req: <= 3)
Antibodies: 1079 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19737.65 (req: >= 5)
Gene RIFs: 2281 (req: > 3)
Antibodies: 1079 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0