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Tbio
CFL1
Cofilin-1

Protein Summary
Description
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308162
  • ENSP00000309629
  • ENSG00000172757
  • ENST00000525451
  • ENSP00000432660

Symbol
  • CFL
  • CFL
  • cofilin
  • HEL-S-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
biological process
0.98
transcription factor binding site profile
0.98
biological term
0.95
hub protein
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1454.96   (req: < 5)
Gene RIFs: 149   (req: <= 3)
Antibodies: 963   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1454.96   (req: >= 5)
Gene RIFs: 149   (req: > 3)
Antibodies: 963   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
77.7
neutrophil count
2
2
2
73.6
leukocyte count
1
1
1
38.9
birth weight
1
1
1
18.3
platelet count
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
77.7
neutrophil count
2
73.6
leukocyte count
1
38.9
birth weight
1
18.3
platelet count
1
17.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cofilin 1
VGNC:6759
745772
Macaque
cofilin 1
721882
Mouse
MGI:101757
12631
Rat
RGD:69285
29271
Dog
cofilin 1
476022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cofilin 1
Macaque
cofilin 1
Mouse
Rat
Dog
cofilin 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23528-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (41)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Gene Ontology Terms (34)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (353)
1 – 10 of 353
CAP2
Tbio
Family: Enzyme
Novelty: 0.1142507
p_int: 0.999720318
p_ni: 0.000279682
Score: 0.927
Data Source: BioPlex,STRINGDB
CAP1
Tbio
Family: Enzyme
Novelty: 0.0333464
p_int: 0.963118194
p_ni: 0.036881806
Score: 0.957
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.879026561
p_ni: 0.120973439
Score: 0.598
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
Score: 0.999
Data Source: STRINGDB
LIMK1
Tchem
Family: Kinase
Novelty: 0.00349854
Score: 0.997
Data Source: Reactome,STRINGDB
ACTG1
Tbio
Novelty: 0.00086444
Score: 0.997
Data Source: STRINGDB
SSH1
Tbio
Family: Enzyme
Novelty: 0.02079383
Score: 0.993
Data Source: STRINGDB
ACTA1
Tbio
Novelty: 0.00111813
Score: 0.991
Data Source: STRINGDB
LIMK2
Tchem
Family: Kinase
Novelty: 0.0153308
Score: 0.991
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  1454.96

PubMed score by year
PubTator Score  835.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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