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Tchem
AHCY
Adenosylhomocysteinase

Protein Classes
Protein Summary
Description
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217426
  • ENSP00000217426
  • ENSG00000101444
  • ENST00000538132
  • ENSP00000442820

Symbol
  • SAHH
  • SAHH
  • adoHcyase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
interacting protein
0.98
transcription factor binding site profile
0.82
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 606.86   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 606.86   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 108
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
5
94.9
glomerular filtration rate
1
1
1
81.5
heel bone mineral density
2
2
2
77.3
sex hormone-binding globulin measurement
2
1
2
46.9
feeling nervous measurement
1
1
0
6.3
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
94.9
glomerular filtration rate
1
81.5
heel bone mineral density
2
77.3
sex hormone-binding globulin measurement
2
46.9
feeling nervous measurement
0
6.3
40.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosylhomocysteinase
VGNC:6035
458190
Macaque
adenosylhomocysteinase
708183
Mouse
MGI:87968
269378
Mouse
MGI:3643647
11615
Rat
RGD:69260
29443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosylhomocysteinase
Macaque
adenosylhomocysteinase
Mouse
Mouse
Rat
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23526-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Metabolic disorders of biological oxidation enzymes
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Disease
Diseases of metabolism
Metabolic disorders of biological oxidation enzymes
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (185)
1 – 10 of 185
C1orf50
Tdark
Novelty:  3.75229996
p_int:  1
Score:  0.923
Data Source:  BioPlex,STRINGDB
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.991064695
p_ni:  0.008935305
Score:  0.351
Data Source:  BioPlex,STRINGDB
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.922976022
p_ni:  0.077023978
Score:  0.868
Data Source:  BioPlex,STRINGDB
BHMT
Tchem
Family:  Enzyme
Novelty:  0.00453508
Score:  0.978
Data Source:  STRINGDB
MTR
Tbio
Family:  Enzyme
Novelty:  0.0006987
Score:  0.978
Data Source:  STRINGDB
CBSL
Tdark
Novelty:  0.00062189
Score:  0.977
Data Source:  STRINGDB
DNMT1
Tclin
Family:  Enzyme
Novelty:  0.00042336
Score:  0.96
Data Source:  STRINGDB
BHMT2
Tchem
Family:  Enzyme
Novelty:  0.07713739
Score:  0.959
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.953
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.941
Data Source:  STRINGDB
Publication Statistics
PubMed Score  606.86

PubMed score by year
PubTator Score  236.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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