Tbio NFYA Nuclear transcription factor Y subunit alpha

Protein Summary

Description

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P23511
• Q8IXU0

Gene Name

• NFYA

Ensembl ID

• ENST00000341376
• ENSP00000345702
• ENSG00000001167
• ENST00000353205
• ENSP00000229418

Symbol

• HAP2
• CBF-A
• CBF-B
• NF-YA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
transcription factor binding site profile	0.84
histone modification site profile	0.81
transcription factor perturbation	0.8
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Transcription Factor Y Subunit Alpha

Protein / Nucleic Acid Binding / Nuclear Transcription Factor Y Subunit Alpha

DTO Classes

Protein / Nucleic Acid Binding / Nuclear Transcription Factor Y Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.66   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.66   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0