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Tbio
NFYA
Nuclear transcription factor Y subunit alpha

Protein Summary
Description
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represente ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341376
  • ENSP00000345702
  • ENSG00000001167
  • ENST00000353205
  • ENSP00000229418

Symbol
  • HAP2
  • CBF-A
  • CBF-B
  • NF-YA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor binding site profile
0.84
histone modification site profile
0.81
transcription factor perturbation
0.8
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.91   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.91   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (134)
1 – 10 of 134
NFYC
Tbio
Family:  TF
Novelty:  0.00626931
p_int:  0.999938016
p_ni:  0.000061984
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
IRGQ
Tdark
Family:  Enzyme
Novelty:  0.9065415
p_int:  0.992285968
p_ni:  0.007713957
p_wrong:  7.5e-8
Score:  0.455
Data Source:  BioPlex,STRINGDB
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
p_int:  0.988067329
p_ni:  0.011932671
Score:  0.956
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.987141634
p_ni:  0.012858343
p_wrong:  2.3e-8
Data Source:  BioPlex
EIF4EBP2
Tbio
Novelty:  0.01926413
p_int:  0.985200231
p_ni:  0.006038371
p_wrong:  0.008761397
Score:  0.228
Data Source:  BioPlex,STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
p_int:  0.974249295
p_ni:  0.015781272
p_wrong:  0.009969433
Score:  0.169
Data Source:  BioPlex,STRINGDB
FTO
Tchem
Family:  Enzyme
Novelty:  0.00053473
p_int:  0.918026942
p_ni:  0.081973058
Score:  0.173
Data Source:  BioPlex,STRINGDB
TES
Tbio
Novelty:  0.00052221
p_int:  0.885172223
p_ni:  0.114802431
p_wrong:  0.000025346
Score:  0.18
Data Source:  BioPlex,STRINGDB
SERPINB1
Tbio
Family:  Enzyme
Novelty:  0.00267786
p_int:  0.877382972
p_ni:  0.12261389
p_wrong:  0.000003138
Score:  0.169
Data Source:  BioPlex,STRINGDB
LASP1
Tbio
Novelty:  0.00960538
p_int:  0.861536952
p_ni:  0.138451071
p_wrong:  0.000011978
Score:  0.206
Data Source:  BioPlex,STRINGDB
Pathways (26)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
ATF6 (ATF6-alpha) activates chaperone genes
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
FOXO-mediated transcription
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperones
Activation of gene expression by SREBF (SREBP)
FOXO-mediated transcription
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
late-onset Alzheimers disease
2
3
0
1.7
90.5
monocyte count
2
2
2
87.7
2
3
0
5.5
79.3
leukocyte count
2
2
2
76.2
C-C motif chemokine 20 measurement
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
late-onset Alzheimers disease
0
1.7
90.5
monocyte count
2
87.7
0
5.5
79.3
leukocyte count
2
76.2
C-C motif chemokine 20 measurement
1
68.8
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear transcription factor Y subunit alpha
VGNC:3588
748395
Macaque
nuclear transcription factor Y subunit alpha
719697
Mouse
MGI:97316
18044
Rat
RGD:70976
29508
Dog
nuclear transcription factor Y subunit alpha
VGNC:43790
474897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear transcription factor Y subunit alpha
Macaque
nuclear transcription factor Y subunit alpha
Mouse
Rat
Dog
nuclear transcription factor Y subunit alpha
Publication Statistics
PubMed Score 204.91
PubMed score by year
PubTator Score 88.77
PubTator score by year