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Tbio
TNFSF4
Tumor necrosis factor ligand superfamily member 4

Protein Summary
Description
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281834
  • ENSP00000281834
  • ENSG00000117586
  • ENST00000367718
  • ENSP00000356691

Symbol
  • TXGP1
  • GP34
  • CD252
  • OX4OL
  • TXGP1
  • CD134L
  • OX-40L
  • TNLG2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.75
disease
0.72
gene perturbation
0.66
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.91   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 663   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.91   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 663   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
TNFRSF4
Tchem
Novelty:  0.0022254
Score:  0.999
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.925
Data Source:  STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.877
Data Source:  STRINGDB
TSLP
Tbio
Novelty:  0.00140333
Score:  0.857
Data Source:  STRINGDB
TNFSF9
Tbio
Novelty:  0.00532152
Score:  0.767
Data Source:  STRINGDB
IL33
Tbio
Novelty:  0.00072064
Score:  0.733
Data Source:  STRINGDB
CD70
Tbio
Novelty:  0.00420393
Score:  0.731
Data Source:  STRINGDB
CD40
Tchem
Novelty:  0.0002836
Score:  0.725
Data Source:  STRINGDB
ICOSLG
Tbio
Novelty:  0.00693966
Score:  0.723
Data Source:  STRINGDB
CD80
Tclin
Novelty:  0.00031181
Score:  0.718
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (136)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
8
0
1.3
94.4
childhood onset asthma
2
2
0
1.1
79.8
4
3
0
1.1
73.8
3
2
2
1
66
2
1
0
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
94.4
childhood onset asthma
0
1.1
79.8
0
1.1
73.8
2
1
66
0
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 4
VGNC:7014
469586
Macaque
TNF superfamily member 4
706255
Mouse
MGI:104511
22164
Rat
RGD:619816
89814
Dog
TNF superfamily member 4
VGNC:47672
100855878
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 4
Macaque
TNF superfamily member 4
Mouse
Rat
Dog
TNF superfamily member 4
Publication Statistics
PubMed Score 367.91
PubMed score by year
PubTator Score 175.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title