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Tbio
TNFSF4
Tumor necrosis factor ligand superfamily member 4

Protein Summary
Description
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281834
  • ENSP00000281834
  • ENSG00000117586
  • ENST00000367718
  • ENSP00000356691

Symbol
  • TXGP1
  • GP34
  • CD252
  • OX4OL
  • TXGP1
  • CD134L
  • OX-40L
  • TNLG2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.75
disease
0.72
gene perturbation
0.66
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.65   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 663   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.65   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 663   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
0
1.3
97.7
Eczema
2
1
0
1
83.5
2
1
0
1
83.5
2
1
0
1
79.8
childhood onset asthma
1
1
0
1.1
36.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
97.7
Eczema
0
1
83.5
0
1
83.5
0
1
79.8
childhood onset asthma
0
1.1
36.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (136)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (112)
1 – 10 of 112
TNFRSF4
Tchem
Novelty: 0.0022254
Score: 0.999
Data Source: Reactome,STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.925
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.877
Data Source: STRINGDB
TSLP
Tbio
Novelty: 0.00140333
Score: 0.857
Data Source: STRINGDB
TNFSF9
Tbio
Novelty: 0.00532152
Score: 0.767
Data Source: STRINGDB
IL33
Tbio
Novelty: 0.00072064
Score: 0.733
Data Source: STRINGDB
CD70
Tbio
Novelty: 0.00420393
Score: 0.731
Data Source: STRINGDB
CD40
Tchem
Novelty: 0.0002836
Score: 0.725
Data Source: STRINGDB
ICOSLG
Tbio
Novelty: 0.00693966
Score: 0.723
Data Source: STRINGDB
CD80
Tclin
Novelty: 0.00031181
Score: 0.718
Data Source: STRINGDB
Publication Statistics
PubMed Score  355.65

PubMed score by year
PubTator Score  175.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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