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Tbio
SP100
Nuclear autoantigen Sp-100

Protein Summary
Description
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. This gene encodes a subnuclear organelle and major component of t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264052
  • ENSP00000264052
  • ENSG00000067066
  • ENST00000340126
  • ENSP00000343023
  • ENST00000409112
  • ENSP00000386427
  • ENST00000409341
  • ENSP00000386404
  • ENST00000409897
  • ENSP00000386998
  • ENST00000427101
  • ENSP00000399389

Symbol
  • lysp100b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological process
0.97
transcription factor perturbation
0.96
ligand (protein) perturbation
0.83
molecular function
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 443.59   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 443.59   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
2
2
78.5
sex hormone-binding globulin measurement
2
1
2
57.8
monocyte count
1
1
1
40.7
lymphocyte percentage of leukocytes
1
1
1
27.3
lymphoid leukemia
1
1
0
1.3
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
78.5
sex hormone-binding globulin measurement
2
57.8
monocyte count
1
40.7
lymphocyte percentage of leukocytes
1
27.3
lymphoid leukemia
0
1.3
14.2
Protein Structure (120 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23497-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 120
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Metabolism of proteins
Gene Ontology Terms (41)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (255)
1 – 10 of 255
HMGB1
Tchem
Family:  TF
Novelty:  0.00043845
p_int:  0.999999995
p_wrong:  5e-9
Score:  0.419
Data Source:  BioPlex,STRINGDB
ZNF706
Tdark
Novelty:  0.30999047
p_int:  0.819381864
p_ni:  0.000017075
p_wrong:  0.180601061
Score:  0.692
Data Source:  BioPlex,STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.986
Data Source:  Reactome,STRINGDB
NUP210
Tbio
Novelty:  0.00784579
Score:  0.983
Data Source:  STRINGDB
PML
Tbio
Novelty:  0.00285474
Score:  0.98
Data Source:  STRINGDB
DAXX
Tbio
Novelty:  0.00348585
Score:  0.98
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.972
Data Source:  Reactome,STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.97
Data Source:  Reactome,STRINGDB
RANBP2
Tbio
Family:  Enzyme
Novelty:  0.00484823
Score:  0.964
Data Source:  STRINGDB
TRIM21
Tbio
Family:  Enzyme
Novelty:  0.00069504
Score:  0.951
Data Source:  STRINGDB
Publication Statistics
PubMed Score  443.59

PubMed score by year
PubTator Score  152.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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