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Tbio
PTPRZ1
Receptor-type tyrosine-protein phosphatase zeta

Protein Summary
Description
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393386
  • ENSP00000377047
  • ENSG00000106278
  • ENST00000449182
  • ENSP00000410000

Symbol
  • HTPZP2
  • PTPRZ
  • PTPRZ2
  • PTPZ
  • PTPZ
  • HPTPZ
  • PTP18
  • PTPRZ
  • RPTPB
  • HPTPzeta
  • PTP-ZETA
  • RPTPbeta
  • phosphacan
  • R-PTP-zeta-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
protein domain
0.92
gene perturbation
0.73
molecular function
0.6
biological term
0.58


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.18   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.18   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type Z1
VGNC:8740
463681
Macaque
protein tyrosine phosphatase, receptor type Z1
574174
Mouse
MGI:97816
19283
Rat
RGD:3455
25613
Dog
protein tyrosine phosphatase, receptor type Z1
VGNC:54793
482428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type Z1
Macaque
protein tyrosine phosphatase, receptor type Z1
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type Z1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23471-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Other interleukin signaling
Signaling by Interleukins
Protein-Protein Interactions (112)
1 – 10 of 112
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.887722856
p_ni: 6e-9
p_wrong: 0.112277138
Score: 0.232
Data Source: BioPlex,STRINGDB
CNTN1
Tbio
Novelty: 0.00741212
Score: 0.989
Data Source: STRINGDB
IL34
Tbio
Novelty: 0.00838631
Score: 0.932
Data Source: Reactome,STRINGDB
PTN
Tbio
Novelty: 0.00129524
Score: 0.922
Data Source: STRINGDB
NCAN
Tbio
Novelty: 0.00401824
Score: 0.918
Data Source: STRINGDB
BCAN
Tbio
Novelty: 0.00737982
Score: 0.851
Data Source: STRINGDB
ALK
Tclin
Family: Kinase
Novelty: 0.00022375
Score: 0.829
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.761
Data Source: STRINGDB
CNTN2
Tbio
Novelty: 0.00213251
Score: 0.753
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.744
Data Source: STRINGDB
Publication Statistics
PubMed Score  200.18

PubMed score by year
PubTator Score  86.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer