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Tchem
PTPRG
Receptor-type tyrosine-protein phosphatase gamma

Protein Summary
Description
Possesses tyrosine phosphatase activity. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295874
  • ENSP00000295874
  • ENSG00000144724
  • ENST00000474889
  • ENSP00000418112

Symbol
  • PTPG
  • PTPG
  • HPTPG
  • RPTPG
  • R-PTP-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor perturbation
0.97
protein domain
0.92
microRNA
0.8
disease
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.03   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.03   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
85.7
body mass index
1
1
1
53.2
smoking status measurement
1
1
0
1
37.5
1
1
0
5.5
27.7
age at onset
1
1
0
5.5
27.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
85.7
body mass index
1
53.2
smoking status measurement
0
1
37.5
0
5.5
27.7
age at onset
0
5.5
27.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type G
VGNC:12160
460484
Macaque
protein tyrosine phosphatase, receptor type G
703937
Mouse
MGI:97814
19270
Rat
RGD:620774
171357
Dog
protein tyrosine phosphatase, receptor type G
VGNC:45188
484706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type G
Macaque
protein tyrosine phosphatase, receptor type G
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type G
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (99)
1 – 10 of 99
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999863346
p_ni: 0.000136654
Data Source: BioPlex
TMEM185A
Tdark
Novelty: 0.0262898
p_int: 0.996788663
p_ni: 0.003211337
Data Source: BioPlex
GJB7
Tbio
Novelty: 0.12555147
p_int: 0.994689253
p_ni: 0.005310747
Score: 0.157
Data Source: BioPlex,STRINGDB
SDC1
Tbio
Novelty: 0.00044792
p_int: 0.992002567
p_ni: 0.007997433
Score: 0.154
Data Source: BioPlex,STRINGDB
DUS4L
Tbio
Family: Enzyme
Novelty: 0.05943255
p_int: 0.990977078
p_ni: 0.009022922
Score: 0.157
Data Source: BioPlex,STRINGDB
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.990450092
p_ni: 0.009549908
Data Source: BioPlex
CCNL2
Tbio
Novelty: 0.03667817
p_int: 0.980295206
p_ni: 0.019704758
p_wrong: 3.6e-8
Data Source: BioPlex
PCDHGC3
Tbio
Novelty: 0.07203024
p_int: 0.97996399
p_ni: 0.02003601
Score: 0.264
Data Source: BioPlex,STRINGDB
DUSP22
Tbio
Family: Enzyme
Novelty: 0.01579003
p_int: 0.977405248
p_ni: 0.022594697
p_wrong: 5.5e-8
Score: 0.311
Data Source: BioPlex,STRINGDB
ISG20
Tbio
Novelty: 0.02450525
p_int: 0.977274745
p_ni: 0.022725255
Data Source: BioPlex
Publication Statistics
PubMed Score  56.03

PubMed score by year
PubTator Score  44.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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