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Tbio
PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

Protein Summary
Description
Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254667
  • ENSP00000254667
  • ENSG00000132334
  • ENST00000306042
  • ENSP00000303350

Symbol
  • PTPE
  • HPTPE
  • R-PTP-EPSILON
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
disease perturbation
0.87
kinase perturbation
0.84
transcription factor binding site profile
0.76
gene perturbation
0.74


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 455   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type E
VGNC:10455
450865
Macaque
protein tyrosine phosphatase, receptor type E
704188
Mouse
MGI:97813
19267
Rat
RGD:620771
114767
Dog
protein tyrosine phosphatase, receptor type E
VGNC:45186
609852
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type E
Macaque
protein tyrosine phosphatase, receptor type E
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type E
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23469-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (46)
1 – 10 of 46
PTPRA
Tchem
Family:  Enzyme
Novelty:  0.01392344
p_int:  1
Score:  0.529
Data Source:  BioPlex,STRINGDB
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
p_int:  0.808282272
p_ni:  0.069637285
p_wrong:  0.122080442
Score:  0.369
Data Source:  BioPlex,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.918
Data Source:  STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.914
Data Source:  STRINGDB
IL6R
Tclin
Novelty:  0.00185005
Score:  0.904
Data Source:  STRINGDB
IL6ST
Tclin
Novelty:  0.01026472
Score:  0.903
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.901
Data Source:  STRINGDB
LMO4
Tbio
Novelty:  0.08806373
Score:  0.9
Data Source:  STRINGDB
SLITRK2
Tbio
Novelty:  0.18828177
Score:  0.73
Data Source:  STRINGDB
SLITRK1
Tbio
Novelty:  0.0132455
Score:  0.73
Data Source:  STRINGDB
Publication Statistics
PubMed Score  26.66

PubMed score by year
PubTator Score  12.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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