Tbio PTPRE Receptor-type tyrosine-protein phosphatase epsilon

Protein Summary

Description

Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P23469
• Q13345
• Q5VWH3
• Q5VWH4
• Q96KQ6
• Protein-tyrosine phosphatase epsilon

Gene Name

• PTPRE

Ensembl ID

• ENST00000254667
• ENSP00000254667
• ENSG00000132334
• ENST00000306042
• ENSP00000303350

Symbol

• PTPE
• HPTPE
• R-PTP-EPSILON

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.91
disease perturbation	0.87
kinase perturbation	0.84
transcription factor binding site profile	0.76
gene perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase Epsilon

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase Epsilon

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.97   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 455   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.97   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0