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Tbio
PTPRD
Receptor-type tyrosine-protein phosphatase delta

Protein Summary
Description
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355233
  • ENSP00000347373
  • ENSG00000153707
  • ENST00000356435
  • ENSP00000348812
  • ENST00000381196
  • ENSP00000370593
  • ENST00000397606
  • ENSP00000380731
  • ENST00000397611
  • ENSP00000380735
  • ENST00000486161
  • ENSP00000417093
  • ENST00000540109
  • ENSP00000438164
  • ENST00000634556
  • ENSP00000489063
  • ENSG00000282932
  • ENST00000634583
  • ENSP00000489509
  • ENST00000634608
  • ENSP00000489257
  • ENST00000635012
  • ENSP00000489439
  • ENST00000635279
  • ENSP00000488982
  • ENST00000635611
  • ENSP00000489155
  • ENST00000635613
  • ENSP00000489038

Symbol
  • HPTP
  • PTPD
  • HPTPD
  • HPTPDELTA
  • RPTPDELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.99
PubMedID
0.87
disease
0.85
microRNA
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.67   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.67   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (50)
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
0
1.3
96.1
3
4
0
1.3
96.1
chronotype measurement
2
3
2
1
79.4
chronotype measurement
2
3
2
1
79.4
insomnia measurement
1
2
0
1.1
78.7
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
96.1
0
1.3
96.1
chronotype measurement
2
1
79.4
chronotype measurement
2
1
79.4
insomnia measurement
0
1.1
78.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type D
VGNC:9193
464991
Macaque
protein tyrosine phosphatase, receptor type D
714954
Mouse
MGI:97812
19266
Rat
RGD:1561090
313278
Dog
protein tyrosine phosphatase, receptor type D
VGNC:45185
481538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type D
Macaque
protein tyrosine phosphatase, receptor type D
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type D
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23468-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Receptor-type tyrosine-protein phosphatases
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Receptor-type tyrosine-protein phosphatases
Synaptic adhesion-like molecules
Protein-Protein Interactions (169)
1 – 10 of 169
LRRN1
Tbio
Novelty:  0.08908267
p_int:  0.994830991
p_ni:  0.005164879
p_wrong:  0.00000413
Score:  0.396
Data Source:  BioPlex,STRINGDB
PCDHB16
Tdark
Novelty:  0.67206411
p_int:  0.9944295
p_ni:  0.005561096
p_wrong:  0.000009404
Score:  0.228
Data Source:  BioPlex,STRINGDB
PIANP
Tbio
Novelty:  0.01739512
p_int:  0.99161352
p_ni:  0.007773915
p_wrong:  0.000612565
Score:  0.194
Data Source:  BioPlex,STRINGDB
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.990420707
p_ni:  0.00953566
p_wrong:  0.000043633
Data Source:  BioPlex
CD83
Tbio
Novelty:  0.00138653
p_int:  0.989679929
p_ni:  0.010315206
p_wrong:  0.000004865
Data Source:  BioPlex
PCDHB1
Tdark
Novelty:  0.93001191
p_int:  0.987815393
p_ni:  0.012184576
p_wrong:  3.1e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
LAMTOR1
Tbio
Novelty:  0.04952213
p_int:  0.980028141
p_ni:  0.019849028
p_wrong:  0.000122831
Data Source:  BioPlex
ICOSLG
Tbio
Novelty:  0.00693966
p_int:  0.978439419
p_ni:  0.021549691
p_wrong:  0.00001089
Data Source:  BioPlex
MCOLN2
Tchem
Family:  IC
Novelty:  0.05195244
p_int:  0.978411839
p_ni:  0.0215881
p_wrong:  6.1e-8
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.974209191
p_ni:  0.025776869
p_wrong:  0.00001394
Data Source:  BioPlex
Publication Statistics
PubMed Score  108.67

PubMed score by year
PubTator Score  87.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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