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Tchem
PTPRB
Receptor-type tyrosine-protein phosphatase beta

Protein Summary
Description
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transf ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261266
  • ENSP00000261266
  • ENSG00000127329
  • ENST00000334414
  • ENSP00000334928
  • ENST00000538708
  • ENSP00000438927
  • ENST00000550857
  • ENSP00000447302

Symbol
  • PTPB
  • PTPB
  • HPTPB
  • VEPTP
  • HPTP-BETA
  • R-PTP-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
protein domain
0.85
disease perturbation
0.83
PubMedID
0.82
cell type or tissue
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.14   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.14   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 120
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (168)
1 – 10 of 168
ITGB2
Tclin
Novelty: 0.00237551
Score: 0.923
Data Source: STRINGDB
PTPRJ
Tbio
Family: Enzyme
Novelty: 0.00998711
Score: 0.921
Data Source: STRINGDB
SPRY3
Tbio
Novelty: 0.10243032
Score: 0.917
Data Source: STRINGDB
CD47
Tchem
Novelty: 0.00158939
Score: 0.916
Data Source: STRINGDB
SIRPA
Tbio
Family: Enzyme
Novelty: 0.00214138
Score: 0.916
Data Source: STRINGDB
AP1M1
Tbio
Novelty: 0.05716619
Score: 0.91
Data Source: STRINGDB
RAB14
Tbio
Family: Enzyme
Novelty: 0.02797855
Score: 0.91
Data Source: STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00085585
Score: 0.909
Data Source: STRINGDB
RAB37
Tbio
Family: Enzyme
Novelty: 0.09047828
Score: 0.908
Data Source: STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00466391
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  129.14

PubMed score by year
PubTator Score  57.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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