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Tchem
PTPRB
Receptor-type tyrosine-protein phosphatase beta

Protein Summary
Description
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transf ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261266
  • ENSP00000261266
  • ENSG00000127329
  • ENST00000334414
  • ENSP00000334928
  • ENST00000538708
  • ENSP00000438927
  • ENST00000550857
  • ENSP00000447302

Symbol
  • PTPB
  • PTPB
  • HPTPB
  • VEPTP
  • HPTP-BETA
  • R-PTP-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
protein domain
0.85
disease perturbation
0.83
PubMedID
0.82
cell type or tissue
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.1   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.1   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 120
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
10.8
78.1
apolipoprotein A 1 measurement
1
1
1
42.3
blood protein measurement
1
1
1
35
intraocular pressure measurement
1
1
1
24.5
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
10.8
78.1
apolipoprotein A 1 measurement
1
42.3
blood protein measurement
1
35
intraocular pressure measurement
1
24.5
high density lipoprotein cholesterol measurement
1
21.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type B
VGNC:52073
452074
Macaque
protein tyrosine phosphatase, receptor type B
718564
Mouse
MGI:97809
19263
Rat
RGD:1305922
314843
Dog
protein tyrosine phosphatase, receptor type B
VGNC:45183
481162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type B
Macaque
protein tyrosine phosphatase, receptor type B
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type B
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23467-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (168)
1 – 10 of 168
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.923
Data Source:  STRINGDB
PTPRJ
Tbio
Family:  Enzyme
Novelty:  0.00786921
Score:  0.921
Data Source:  STRINGDB
SPRY3
Tbio
Novelty:  0.06114906
Score:  0.917
Data Source:  STRINGDB
CD47
Tchem
Novelty:  0.00129086
Score:  0.916
Data Source:  STRINGDB
SIRPA
Tbio
Family:  Enzyme
Novelty:  0.0021102
Score:  0.916
Data Source:  STRINGDB
AP1M1
Tbio
Novelty:  0.029282
Score:  0.91
Data Source:  STRINGDB
RAB14
Tbio
Family:  Enzyme
Novelty:  0.01876172
Score:  0.91
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.909
Data Source:  STRINGDB
RAB37
Tbio
Family:  Enzyme
Novelty:  0.07133253
Score:  0.908
Data Source:  STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.908
Data Source:  STRINGDB
Publication Statistics
PubMed Score  133.10

PubMed score by year
PubTator Score  57.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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